Renee Read, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-5985
Email Address

renee.read@emory.edu

Biography

Renee Read, PhD, is an associate professor in the Department of Pharmacology and Chemical Biology at Emory University School of Medicine. Dr. Read serves as assistant director for basic research and shared resources and is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Read earned her PhD in Developmental Biology from the University of Washington. She then completed a postdoctoral fellowship at The Salk Institute for Biological Studies.

Titles & Roles

Associate Professor, Department of Pharmacology and Chemical Biology

Emory University School of Medicine
Assistant Director for Basic Research and Shared Resources

Winship Cancer Institute of Emory University

Research

Dr. Read's lab seeks to understand the molecular logic underlying the initiation and progression of primary brain tumors in order to gain new insights into neurodevelopment and neurophysiology that can contribute to improved treatment and diagnosis of these diseases. Glioblastomas, the most common and deadly primary brain tumors, display signature genetic lesions that perturb the activity of genes that normally regulate essential developmental and homeostatic processes in the central nervous system. In particular, the most common mutations found in glioblastomas result in constitutive activation of receptor tyrosine kinase (RTK) and Pi-3 kinase (PI3K) signaling pathways. Yet, how these mutations drive tumorigenesis is unclear, and how to effectively target these pathways therapeutically remains to be determined. Her research program is designed to discover new regulators of gliomagenesis using multidisciplinary genetic and molecular approaches.

Publications

Title/Journal	Authors	Publication Date
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration. The Journal of biological chemistry	PM Zakutansky, L Ku, G Zhang, L Shi, Y Li, B Yao, GJ Bassell, RD Read, Y Feng	08/01/2024
Glioblastoma microenvironment-from biology to therapy. Genes & development	RD Read, ZM Tapp, P Rajappa, D Hambardzumyan	06/25/2024
A protocol to use Drosophila melanogaster larvae to model human glioblastoma. STAR protocols	JG Saborio, EE Young, AS Chen, RD Read	09/16/2022
Repurposing the drug verteporfin as anti-neoplastic therapy for glioblastoma. Neuro-oncology	RD Read	05/04/2022
YAP/TAZ Transcriptional Coactivators Create Therapeutic Vulnerability to Verteporfin in EGFR-mutant Glioblastoma. Clinical cancer research : an official journal of the American Association for Cancer Research	K Vigneswaran, NH Boyd, SY Oh, S Lallani, A Boucher, SG Neill, JJ Olson, RD Read	03/01/2021
Platelet-derived growth factor beta is a potent inflammatory driver in paediatric high-grade glioma. Brain : a journal of neurology	JL Ross, Z Chen, CJ Herting, Y Grabovska, F Szulzewsky, M Puigdelloses, L Monterroza, J Switchenko, NR Wadhwani, PJ Cimino, A Mackay, C Jones, RD Read, TJ MacDonald, M Schniederjan, OJ Becher, D Hambardzumyan	02/12/2021
Reuse of Molecules for Glioblastoma Therapy. Pharmaceuticals (Basel, Switzerland)	A Koehler, A Karve, P Desai, J Arbiser, DR Plas, X Qi, RD Read, AT Sasaki, VS Gawali, DK Toukam, D Bhattacharya, L Kallay, DA Pomeranz Krummel, S Sengupta	01/28/2021
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade. Glia	Z Chen, CJ Herting, JL Ross, B Gabanic, M Puigdelloses Vallcorba, F Szulzewsky, ML Wojciechowicz, PJ Cimino, R Ezhilarasan, EP Sulman, M Ying, A Ma'ayan, RD Read, D Hambardzumyan	10/01/2020
Upregulation of the chromatin remodeler HELLS is mediated by YAP1 in Sonic Hedgehog Medulloblastoma. Scientific reports	MH Robinson, V Maximov, S Lallani, H Farooq, MD Taylor, RD Read, AM Kenney	09/20/2019
Drak/STK17A Drives Neoplastic Glial Proliferation through Modulation of MRLC Signaling. Cancer research	AS Chen, J Wardwell-Ozgo, NN Shah, D Wright, CL Appin, K Vigneswaran, DJ Brat, HI Kornblum, RD Read	03/15/2019
Drosophila melanogaster as a Model System for Human Glioblastomas. Advances in experimental medicine and biology	AS Chen, RD Read	01/01/2019
Pvr receptor tyrosine kinase signaling promotes post-embryonic morphogenesis, and survival of glia and neural progenitor cells in Drosophila. Development (Cambridge, England)	RD Read	12/04/2018
CDK5 Inhibition Resolves PKA/cAMP-Independent Activation of CREB1 Signaling in Glioma Stem Cells. Cell reports	S Mukherjee, C Tucker-Burden, E Kaissi, A Newsam, H Duggireddy, M Chau, C Zhang, B Diwedi, M Rupji, S Seby, J Kowalski, J Kong, R Read, DJ Brat	05/08/2018
Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport. Cancer research	S Mukherjee, C Tucker-Burden, C Zhang, K Moberg, R Read, C Hadjipanayis, DJ Brat	04/15/2016
A kinome-wide RNAi screen in Drosophila Glia reveals that the RIO kinases mediate cell proliferation and survival through TORC2-Akt signaling in glioblastoma. PLoS genetics	RD Read, TR Fenton, GG Gomez, J Wykosky, SR Vandenberg, I Babic, A Iwanami, H Yang, WK Cavenee, PS Mischel, FB Furnari, JB Thomas	01/01/2013
Drosophila melanogaster as a model system for human brain cancers. Glia	RD Read	09/01/2011

Awards

Dr. Read has earned the following awards and honors:

Pathway to Independence Award, National Institute of Neurological Disorders and Stroke, 2009
Sanofi-Aventis Discovery Grant, Salk-Sanofi Strategic Alliance, 2009
American Brain Tumor Association Postdoctoral Fellowship, 2008
National Research Service Award, National Institute of Neurological Disorders and Stroke, 2005
Jakschik Award and Victor Hamburger Award, in recognition of research excellence at Washington University, 2003, 2002
Nominee, Dean’s Award for Teaching Excellence, Instruction in Biology, Washington University, 1999