Philip Santangelo, PhD
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Research Program
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Phone Number
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Email Address
Biography
Philip Santangelo, PhD, is a professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech School of Engineering and Emory University School of Medicine.
Dr. Santangelo is a member of the Cancer Immunology Research Program at Winship Cancer Institute of Emory University in Atlanta, Georgia.
Education
Dr. Santangelo obtained his PhD in Engineering from the University of California at Davis. He completed his postdoctoral training at Sandia National Laboratories in Livermore, California, and at Georgia Tech in Atlanta. He also holds an MS in Engineering from Purdue University.
Titles & Roles
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Professor, Wallace H. Coulter Department of Biomedical EngineeringGeorgia Institute of Technology and Emory University
Research
The overarching theme of the Santangelo lab is the spatial biology of RNA viruses and RNA regulation. Spatial biology is the study of biology in three dimensions - and the Santangelo lab develops advanced imaging tools to achieve this goal. The lab focuses their tools on the spatial biology of HIV/SIV and human respiratory synctial virus (leading cause of bronchiolitis and pneumonia in babies) and the aberrant regulation of messenger RNA during inflammation, viral infections and cancer pathogenesis. They have developed both single molecule methods and whole body imaging methods in order to work towards our goals.
Publications
| Title/Journal | Authors | Publication Date |
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Nanoparticle delivery of a prodrug-activating bacterial enzyme leads to anti-tumor responses. Nature communications |
SG Huayamares, L Lian, R Rab, Y Hou, A Radmand, H Kim, R Zenhausern, BR Achyut, M Gilbert Ross, MP Lokugamage, D Loughrey, HE Peck, ES Echeverri, AJ Da Silva Sanchez, A Shajii, A Li, KE Tiegreen, PJ Santangelo, EJ Sorscher, JE Dahlman | 04/12/2025 |
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Lipid nanoparticle-mediated mRNA delivery to CD34+ cells in rhesus monkeys. Nature biotechnology |
H Kim, R Zenhausern, K Gentry, L Lian, SG Huayamares, A Radmand, D Loughrey, AR Podilapu, MZC Hatit, H Ni, A Li, A Shajii, HE Peck, K Han, X Hua, S Jia, M Martinez, C Lee, PJ Santangelo, A Tarantal, JE Dahlman | 11/22/2024 |
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Nature biomedical engineering |
DW Wolfson, NK Kim, KH Lee, JP Beyersdorf, JJ Langberg, N Fernandez, D Choi, N Zureick, TY Kim, S Bae, JM Gu, JL Kirschman, J Fan, CY Sheng, D Gottlieb Sen, B Mettler, JH Sung, YS Yoon, SJ Park, PJ Santangelo, HC Cho | 09/01/2024 |
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mRNA-encoded Cas13 can be used to treat dengue infections in mice. Nature microbiology |
M Basu, C Zurla, TT Auroni, D Vanover, LCS Chaves, H Sadhwani, H Pathak, R Basu, JP Beyersdorf, OO Amuda, A Elsharkawy, V Mosur, RA Arthur, H Claussen, LE Sasser, JA Wroe, HE Peck, M Kumar, MA Brinton, PJ Santangelo | 08/01/2024 |
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Advanced healthcare materials |
AJDS Sanchez, D Loughrey, ES Echeverri, SG Huayamares, A Radmand, K Paunovska, M Hatit, KE Tiegreen, PJ Santangelo, JE Dahlman | 07/01/2024 |
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mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens |
LCS Chaves, N Orr-Burks, D Vanover, VV Mosur, SR Hosking, P Kumar E K, H Jeong, Y Jung, JAF Assumpção, HE Peck, SL Nelson, KN Burke, MA Garrison, RA Arthur, H Claussen, NS Heaton, ER Lafontaine, RJ Hogan, C Zurla, PJ Santangelo | 07/01/2024 |
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Cationic cholesterol-dependent LNP delivery to lung stem cells, the liver, and heart. Proceedings of the National Academy of Sciences of the United States of America |
A Radmand, H Kim, J Beyersdorf, CN Dobrowolski, R Zenhausern, K Paunovska, SG Huayamares, X Hua, K Han, D Loughrey, MZC Hatit, A Del Cid, H Ni, A Shajii, A Li, A Muralidharan, HE Peck, KE Tiegreen, S Jia, PJ Santangelo, JE Dahlman | 03/12/2024 |
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Platform-Specific Fc N-Glycan Profiles of an Antisperm Antibody. Antibodies (Basel, Switzerland) |
E Nador, C Xia, PJ Santangelo, KJ Whaley, CE Costello, DJ Anderson | 03/06/2024 |
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Blockade of TGF-β signaling reactivates HIV-1/SIV reservoirs and immune responses in vivo. JCI insight |
S Samer, Y Thomas, M Araínga, C Carter, LM Shirreff, MS Arif, JM Avita, I Frank, MD McRaven, CT Thuruthiyil, VB Heybeli, MR Anderson, B Owen, A Gaisin, D Bose, LM Simons, JF Hultquist, J Arthos, C Cicala, I Sereti, PJ Santangelo, R Lorenzo-Redondo, TJ Hope, FJ Villinger, E Martinelli | 11/22/2023 |
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Frontiers in immunology |
A McNee, D Vanover, P Rijal, B Paudyal, FZX Lean, R MacLoughlin, A Núñez, A Townsend, PJ Santangelo, E Tchilian | 01/01/2023 |