Eric Sorscher, MD

Research Program

Discovery and Developmental Therapeutics
Phone Number

404-727-3293
Email Address

esorscher@emory.edu

Biography

Eric Sorscher, MD, is a professor in the Department of Pediatrics, Division of Pulmonary, Allergy/Immunology, Cystic Fibrosis and Sleep at Emory University School of Medicine.

Dr. Sorscher is a member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute.

Education

Dr. Sorscher his medical degree from Harvard University.

Titles & Roles

Professor, Department of Pediatrics

Emory University School of Medicine

Research

Dr. Sorscher has focused on researching cystic fibrosis related science and intervention for more than 25 years. His research pursues studies of molecular pathogenesis and translational research concerning cancer and cystic fibrosis.

Grants

View Grants

Grant Number	Title
2R01HL136414-05	Discovery of novel mechanisms that impact CFTR translation and contribute to cystic fibrosis pathogenesis
5R01HL136414-06	Discovery of novel mechanisms that impact CFTR translation and contribute to cystic fibrosis pathogenesis
5R01HL136414-07	Discovery of novel mechanisms that impact CFTR translation and contribute to cystic fibrosis pathogenesis
5R01HL139876-05	Rare mutations in Cystic Fibrosis: Overcoming barriers to personalized medicine

Publications

Dr. Sorscher is an inductee of the MilliPub Club, which recognizes current Emory faculty who have published one or more individual papers throughout their careers that have garnered more than 1,000 citations.

Title/Journal	Authors	Publication Date
Evaluating elexacaftor/tezacaftor/ivacaftor (ETI; Trikafta™) for treatment of patients with non-cystic fibrosis bronchiectasis (NCFBE): A clinical study protocol. PloS one	CE Swenson, WR Hunt, C Manfredi, DJ Beltran, JS Hong, BR Davis, S Suzuki, C Barillá, A Rab, C Chico, J Dangerfield, A Streby, E Barton, EM Cox, AA Stecenko, A Westbrook, R Kapolka, EJ Sorscher	01/01/2025
Evaluation of elexacaftor-tezacaftor-ivacaftor treatment in individuals with cystic fibrosis and CFTR^N1303K in the USA: a prospective, multicentre, open-label, single-arm trial. The Lancet. Respiratory medicine	GM Solomon, RW Linnemann, R Rich, A Streby, B Buehler, E Hunter, K Vijaykumar, WR Hunt, JJ Brewington, A Rab, SP Bai, AL Westbrook, C McNicholas-Bevensee, J Hong, C Manfredi, C Barilla, S Suzuki, BR Davis, EJ Sorscher	12/01/2024
Development of robust antiviral assays using relevant apical-out human airway organoids. bioRxiv : the preprint server for biology	JH Lee, JC LeCher, E Parigoris, N Shinagawa, J Sentosa, C Manfredi, SL Goh, R De, S Tao, K Zandi, F Amblard, EJ Sorscher, JR Spence, R Tirouvanziam, RF Schinazi, S Takayama	07/12/2024
Nucleic acid-based drugs for patients with solid tumours. Nature reviews. Clinical oncology	SG Huayamares, D Loughrey, H Kim, JE Dahlman, EJ Sorscher	06/01/2024
Translation velocity determines the efficacy of engineered suppressor tRNAs on pathogenic nonsense mutations. Nature communications	N Bharti, L Santos, M Davyt, S Behrmann, M Eichholtz, A Jimenez-Sanchez, JS Hong, A Rab, EJ Sorscher, S Albers, Z Ignatova	04/05/2024
Mutation accumulation in H. sapiens F508del CFTR countermands dN/dS type genomic analysis. PloS one	JS Hong, JM Tindall, SR Tindall, EJ Sorscher	01/01/2024
Relationships between genomic dissipation and de novo SNP evolution. PloS one	ZE Plyler, CW McAtee, AE Hill, MR Crowley, JM Tindall, SR Tindall, D Joshi, EJ Sorscher	01/01/2024
Mechanisms by which the cystic fibrosis transmembrane conductance regulator may influence SARS-CoV-2 infection and COVID-19 disease severity. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	PR Tedbury, C Manfredi, F Degenhardt, J Conway, MC Horwath, C McCracken, AJ Sorscher, S Moreau, C Wright, C Edwards, J Brewer, J Guarner, E de Wit, BN Williamson, MS Suthar, YT Ong, JD Roback, DN Alter, JC Holter, TH Karlsen, N Sacchi, M Romero-Gómez, P Invernizzi, J Fernández, M Buti, A Albillos, A Julià, L Valenti, R Asselta, JM Banales, L Bujanda, R de Cid, A Franke, SG Sarafianos, JS Hong, EJ Sorscher, A Ehrhardt	11/01/2023
A Novel 7H-[1,2,4]Triazolo[3,4-b]thiadiazine-based Cystic Fibrosis Transmembrane Conductance Regulator Potentiator Directed toward Treatment of Cystic Fibrosis. ACS medicinal chemistry letters	A Rab, X Yang, WF Tracy, JS Hong, D Joshi, C Manfredi, SS Ponnaluri, AA Kolykhalov, M Qui, H Fu, Y Du, HML Davies, EJ Sorscher	10/12/2023
Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics. The Journal of biological chemistry	M Kim, EF McDonald, CMP Sabusap, B Timalsina, D Joshi, JS Hong, A Rab, EJ Sorscher, L Plate	10/01/2023
Engineered tRNAs suppress nonsense mutations in cells and in vivo. Nature	S Albers, EC Allen, N Bharti, M Davyt, D Joshi, CG Perez-Garcia, L Santos, R Mukthavaram, MA Delgado-Toscano, B Molina, K Kuakini, M Alayyoubi, KJ Park, G Acharya, JA Gonzalez, A Sagi, SE Birket, GJ Tearney, SM Rowe, C Manfredi, JS Hong, K Tachikawa, P Karmali, D Matsuda, EJ Sorscher, P Chivukula, Z Ignatova	06/01/2023
High-throughput screens identify a lipid nanoparticle that preferentially delivers mRNA to human tumors in vivo. Journal of controlled release : official journal of the Controlled Release Society	SG Huayamares, MP Lokugamage, R Rab, AJ Da Silva Sanchez, H Kim, A Radmand, D Loughrey, L Lian, Y Hou, BR Achyut, A Ehrhardt, JS Hong, CD Sago, K Paunovska, ES Echeverri, D Vanover, PJ Santangelo, EJ Sorscher, JE Dahlman	05/01/2023
Elexacaftor/VX-445-mediated CFTR interactome remodeling reveals differential correction driven by mutation-specific translational dynamics. bioRxiv : the preprint server for biology	M Kim, EF McDonald, CMP Sabusap, B Timalsina, D Joshi, JS Hong, A Rab, EJ Sorscher, L Plate	02/04/2023
Evaluating antitumor activity of Escherichia coli purine nucleoside phosphorylase against head and neck patient-derived xenografts. Cancer reports (Hoboken, N.J.)	R Rab, A Ehrhardt, BR Achyut, D Joshi, M Gilbert-Ross, C Huang, K Floyd, AV Borovjagin, WB Parker, EJ Sorscher, JS Hong	02/01/2023
Mutation profiling of the c.1521_1523delCTT (p.Phe508del, F508del) cystic fibrosis transmembrane conductance regulator allele using haplotype-resolved long-read next generation sequencing. Human mutation	D Dilernia, P Amin, J Flores, A Stecenko, E Sorscher	05/01/2022
Marine Natural Products as Leads against SARS-CoV-2 Infection. Journal of natural products	BK Chhetri, PR Tedbury, AM Sweeney-Jones, L Mani, K Soapi, C Manfredi, E Sorscher, SG Sarafianos, J Kubanek	03/25/2022
A medium composition containing normal resting glucose that supports differentiation of primary human airway cells. Scientific reports	R Morgan, C Manfredi, KF Easley, LD Watkins, WR Hunt, SL Goudy, EJ Sorscher, M Koval, SA Molina	01/27/2022
Targeted Gene Insertion for Functional CFTR Restoration in Airway Epithelium. Frontiers in genome editing	C Barillà, S Suzuki, A Rab, EJ Sorscher, BR Davis	01/01/2022
Improved correction of F508del-CFTR biogenesis with a folding facilitator and an inhibitor of protein ubiquitination. Bioorganic & medicinal chemistry letters	JL Goeckeler-Fried, R Aldrin Denny, D Joshi, C Hill, MB Larsen, AN Chiang, RA Frizzell, P Wipf, EJ Sorscher, JL Brodsky	09/15/2021
Antisense oligonucleotide-based drug development for Cystic Fibrosis patients carrying the 3849+10 kb C-to-T splicing mutation. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society	YS Oren, M Irony-Tur Sinai, A Golec, O Barchad-Avitzur, V Mutyam, Y Li, J Hong, E Ozeri-Galai, A Hatton, C Leibson, L Carmel, J Reiter, EJ Sorscher, SD Wilton, E Kerem, SM Rowe, I Sermet-Gaudelus, B Kerem	09/01/2021
Association of cystic fibrosis transmembrane conductance regulator with epithelial sodium channel subunits carrying Liddle's syndrome mutations. American journal of physiology. Lung cellular and molecular physiology	AK Rooj, E Cormet-Boyaka, EB Clark, YJ Qadri, W Lee, R Boddu, A Agarwal, R Tambi, M Uddin, V Parpura, EJ Sorscher, CM Fuller, BK Berdiev	08/01/2021
A small molecule that induces translational readthrough of CFTR nonsense mutations by eRF1 depletion. Nature communications	J Sharma, M Du, E Wong, V Mutyam, Y Li, J Chen, J Wangen, K Thrasher, L Fu, N Peng, L Tang, K Liu, B Mathew, RJ Bostwick, CE Augelli-Szafran, H Bihler, F Liang, J Mahiou, J Saltz, A Rab, J Hong, EJ Sorscher, EM Mendenhall, CJ Coppola, KM Keeling, R Green, M Mense, MJ Suto, SM Rowe, DM Bedwell	07/16/2021
LPS decreases CFTR open probability and mucociliary transport through generation of reactive oxygen species. Redox biology	DY Cho, S Zhang, A Lazrak, D Skinner, HM Thompson, J Grayson, P Guroji, S Aggarwal, Z Bebok, SM Rowe, S Matalon, EJ Sorscher, BA Woodworth	07/01/2021
Stability Prediction for Mutations in the Cytosolic Domains of Cystic Fibrosis Transmembrane Conductance Regulator. Journal of chemical information and modeling	MS Bahia, N Khazanov, Q Zhou, Z Yang, C Wang, JS Hong, A Rab, EJ Sorscher, CG Brouillette, JF Hunt, H Senderowitz	04/26/2021
Positive epistasis between disease-causing missense mutations and silent polymorphism with effect on mRNA translation velocity. Proceedings of the National Academy of Sciences of the United States of America	R Rauscher, GB Bampi, M Guevara-Ferrer, LA Santos, D Joshi, D Mark, LJ Strug, JM Rommens, M Ballmann, EJ Sorscher, KE Oliver, Z Ignatova	01/26/2021
The CFTR P67L variant reveals a key role for N-terminal lasso helices in channel folding, maturation, and pharmacologic rescue. The Journal of biological chemistry	CM Sabusap, D Joshi, L Simhaev, KE Oliver, H Senderowitz, M van Willigen, I Braakman, A Rab, EJ Sorscher, JS Hong	01/01/2021
Ivacaftor Reverses Airway Mucus Abnormalities in a Rat Model Harboring a Humanized G551D-CFTR. American journal of respiratory and critical care medicine	SE Birket, JM Davis, CM Fernandez-Petty, AG Henderson, AM Oden, L Tang, H Wen, J Hong, L Fu, A Chambers, A Fields, G Zhao, GJ Tearney, EJ Sorscher, SM Rowe	11/01/2020
Global assessment of the integrated stress response in CF patient-derived airway and intestinal tissues. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society	GB Bampi, R Rauscher, S Kirchner, KE Oliver, MJC Bijvelds, LA Santos, J Wagner, RA Frizzell, HR de Jonge, EJ Sorscher, Z Ignatova	11/01/2020
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. Journal of virology	A Vanderheiden, P Ralfs, T Chirkova, AA Upadhyay, MG Zimmerman, S Bedoya, H Aoued, GM Tharp, KL Pellegrini, C Manfredi, E Sorscher, B Mainou, JL Lobby, JE Kohlmeier, AC Lowen, PY Shi, VD Menachery, LJ Anderson, A Grakoui, SE Bosinger, MS Suthar	09/15/2020
Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction. Molecular therapy : the journal of the American Society of Gene Therapy	S Suzuki, AM Crane, V Anirudhan, C Barillà, N Matthias, SH Randell, A Rab, EJ Sorscher, JL Kerschner, S Yin, A Harris, M Mendel, K Kim, L Zhang, A Conway, BR Davis	07/08/2020
The use of Trichomonas vaginalis purine nucleoside phosphorylase to activate fludarabine in the treatment of solid tumors. Cancer chemotherapy and pharmacology	WB Parker, PW Allan, WR Waud, J Hong, M Gilbert-Ross, BR Achyut, D Joshi, T Behbahani, R Rab, SE Ealick, EJ Sorscher	03/01/2020
Slowing ribosome velocity restores folding and function of mutant CFTR. The Journal of clinical investigation	KE Oliver, R Rauscher, M Mijnders, W Wang, MJ Wolpert, J Maya, CM Sabusap, RA Kesterson, KL Kirk, A Rab, I Braakman, JS Hong, JL Hartman, Z Ignatova, EJ Sorscher	12/02/2019
An Ancient CFTR Ortholog Informs Molecular Evolution in ABC Transporters. Developmental cell	G Cui, J Hong, YW Chung-Davidson, D Infield, X Xu, J Li, L Simhaev, N Khazanov, B Stauffer, B Imhoff, K Cottrill, JE Blalock, W Li, H Senderowitz, E Sorscher, NA McCarty, A Gaggar	11/18/2019
Cystic fibrosis precision therapeutics: Emerging considerations. Pediatric pulmonology	D Joshi, A Ehrhardt, JS Hong, EJ Sorscher	11/01/2019
VX-770-mediated potentiation of numerous human CFTR disease mutants is influenced by phosphorylation level. Scientific reports	G Cui, BB Stauffer, BR Imhoff, A Rab, JS Hong, EJ Sorscher, NA McCarty	09/17/2019
Making precision medicine personal for cystic fibrosis. Science (New York, N.Y.)	C Manfredi, JM Tindall, JS Hong, EJ Sorscher	07/19/2019
Assessing cell-specific effects of genetic variations using tRNA microarrays. BMC genomics	C Polte, D Wedemeyer, KE Oliver, J Wagner, MJC Bijvelds, J Mahoney, HR de Jonge, EJ Sorscher, Z Ignatova	07/16/2019
Intratumoral generation of 2-fluoroadenine to treat solid malignancies of the head and neck. Head & neck	TE Behbahani, EL Rosenthal, WB Parker, EJ Sorscher	06/01/2019

Awards

Dr. Sorscher has been inducted into the American Society of Clinical Investigation and the Association of American Physicians.