Jennifer Spangle, PhD
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Research Program
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Phone Number
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Email Address
Biography
Jennifer M. Spangle, PhD, is an assistant professor in the Department of Radiation Oncology at Emory University School of Medicine. Prior to joining Emory, Dr. Spangle was an instructor of pathology at Dana-Farber Cancer Institute and Harvard Medical School.
Dr. Spangle is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.
Education
Dr. Spangle graduated with honors from the University of Arizona with a BS in Molecular and Cellular Biology. She earned her PhD in Virology from Harvard Medical School in Boston, Massachusetts. She completed her postdoctoral training at Dana-Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts, where she was the American Cancer Society Lee Denim Postdoctoral Fellow.
Titles & Roles
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Assistant Professor, Department of Radiation OncologyEmory University School of Medicine
Research
The Spangle laboratory is committed to understanding how PI3K-mediated regulation of the epigenome contributes to cancer development and modulates treatment response. The PI3K signaling pathways is aberrantly activated in more than 40% of breast and other cancers, and yet mono- and combination therapies resulting in durable PI3K inhibition are still in development. Her research program hopes to utilize PI3K-mediated epigenetic rewiring to identify actionable targets and durable and efficacious combination therapies for the treatment of PI3K-activated cancers. The Spangle lab is specifically focusing on the mechanisms by which H3K4-directed demethylases and methyltransferases mediate resistance to PI3K inhibitors in cancer and how AKT regulates histone phosphorylation and transcriptional competence in normal tissue and how this process is deregulated in cancer.
Grants
| Grant Number | Title |
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| 1R35GM150587-01 | Role of novel histone modifications and variants in transcriptional regulation |
| 5R35GM150587-02 | Role of novel histone modifications and variants in transcriptional regulation |
Publications
| Title/Journal | Authors | Publication Date |
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Dynamic In Vivo Mapping of the Methylproteome Using a Chemoenzymatic Approach. Journal of the American Chemical Society |
J Farhi, B Emenike, RS Lee, K Sad, DV Fawwal, CM Beusch, RB Jones, AK Verma, CY Jones, M Foroozani, M Reeves, KK Parwani, P Bagchi, RB Deal, DJ Katz, AH Corbett, DE Gordon, M Raj, JM Spangle | 03/05/2025 |
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Histone H3E50K remodels chromatin to confer oncogenic activity and support an EMT phenotype. NAR cancer |
K Sad, DV Fawwal, CY Jones, EJ Hill, KT Skinner, ML Adams, S Lustenberger, RS Lee, SV Lohano, SR Elayavalli, J Farhi, CC Mehta, LD Lemon, MB Fasken, AL Hong, SA Sloan, AH Corbett, JM Spangle | 03/01/2025 |
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Histone H3 E50K mutation confers oncogenic activity and supports an EMT phenotype. bioRxiv : the preprint server for biology |
K Sad, CY Jones, DV Fawwal, EJ Hill, K Skinner, S Lustenberger, RS Lee, SR Elayavalli, J Farhi, LD Lemon, MB Fasken, AL Hong, SA Sloan, AH Corbett, JM Spangle | 08/01/2024 |
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Journal of the American Chemical Society |
B Emenike, P Czabala, J Farhi, J Swaminathan, EV Anslyn, J Spangle, M Raj | 04/17/2024 |
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Communications biology |
K Mittal, GW Cooper, BP Lee, Y Su, KT Skinner, J Shim, HC Jonus, WJ Kim, M Doshi, D Almanza, BD Kynnap, AL Christie, X Yang, GS Cowley, BA Leeper, CL Morton, B Dwivedi, T Lawrence, M Rupji, P Keskula, S Meyer, CM Clinton, M Bhasin, BD Crompton, YY Tseng, JS Boehm, KL Ligon, DE Root, AJ Murphy, DM Weinstock, PC Gokhale, JM Spangle, MN Rivera, EA Mullen, K Stegmaier, KC Goldsmith, WC Hahn, AL Hong | 04/08/2024 |
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Tunable fluorescent probes for detecting aldehydes in living systems. Chemical science |
R Wills, R Shirke, H Hrncir, JM Talbott, K Sad, JM Spangle, AD Gracz, M Raj | 03/27/2024 |
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Exploring the Molecular Underpinnings of Cancer-Causing Oncohistone Mutants Using Yeast as a Model. Journal of fungi (Basel, Switzerland) |
X Zhang, DV Fawwal, JM Spangle, AH Corbett, CY Jones | 12/11/2023 |
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Emerging Role of Epigenetic Modifiers in Breast Cancer Pathogenesis and Therapeutic Response. Cancers |
RS Lee, K Sad, DV Fawwal, JM Spangle | 08/07/2023 |
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Identification of ligand-receptor pairs that drive human astrocyte development. Nature neuroscience |
AJ Voss, SN Lanjewar, MM Sampson, A King, EJ Hill, A Sing, C Sojka, TN Bhatia, JM Spangle, SA Sloan | 08/01/2023 |
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Cancer research communications |
RB Jones, J Farhi, M Adams, KK Parwani, GW Cooper, M Zecevic, RS Lee, AL Hong, JM Spangle | 12/01/2022 |
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G3 (Bethesda, Md.) |
LD Lemon, S Kannan, KW Mo, M Adams, HG Choi, AOD Gulka, ES Withers, HT Nurelegne, V Gomez, RE Ambrocio, R Tumminkatti, RS Lee, M Wan, MB Fasken, JM Spangle, AH Corbett | 07/06/2022 |
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Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angewandte Chemie (International ed. in English) |
KC Tang, J Cao, LM Boatner, L Li, J Farhi, KN Houk, J Spangle, KM Backus, M Raj | 01/26/2022 |
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Frontiers in cell and developmental biology |
M Lee, DK Geitgey, JAG Hamilton, JM Boss, CD Scharer, JM Spangle, KA Haynes, CJ Henry | 01/01/2022 |
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Medulloblastoma and the DNA Damage Response. Frontiers in oncology |
LF McSwain, KK Parwani, SW Shahab, D Hambardzumyan, TJ MacDonald, JM Spangle, AM Kenney | 01/01/2022 |
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The Journal of biological chemistry |
JM Spangle, H Ghalei, AH Corbett | 09/01/2021 |
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Proceedings of the National Academy of Sciences of the United States of America |
JM Spangle, T Von, DC Pavlick, A Khotimsky, JJ Zhao, TM Roberts | 09/29/2020 |