H. Trent Spencer, PhD
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Research Program
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Phone Number
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Email Address

H. Trent Spencer, PhD, is a professor in the Department of Pediatrics and director of the Gene and Cell Therapy Program in the Aflac Cancer and Blood Disorders Center. He is a Georgia Cancer Coalition Distinguished Scholar, and his areas of interest include gene therapy, stem cell biology, blood and marrow transplantation and immunotherapy. He is president and co-founder of Expression Therapeutics, a privately owned biotechnology company that is developing therapies for hemophilia A patients. His laboratory has a significant interest in translational research focused on cancer and bleeding disorders, and he has been involved in the submission of several projects leading to investigational new drug applications.
Dr. Spencer is a member of the Cancer Immunology Research Program at Winship Cancer Institute.
Dr. Spencer received his PhD from Creighton University School of Medicine in Omaha, Nebraska. He completed his postdoctoral research at St. Jude Children’s Research Hospital in Memphis, Tennessee.
Dr. Spencer is a member of the American Society of Cell and Gene Therapy and a member of several committees within the society.
The development of gene therapy treatments for childhood cancer and inherited diseases is the major focus of Dr. Spencer's laboratory. His group has pioneered an approach to treat cancer using novel immunotherapies, termed Drug Resistance Immunotherapy (DRI). His lab is testing if immunocompetent cells can be genetically engineered to withstand the toxic effects of chemotherapy, and if so, whether the genetic modification can allow for the combined use of chemotherapy and cell-based immunotherapy, which may result in increased survival with reduced chemotherapy administration compared to individual chemotherapy or immunotherapy treatments. His group has also developed novel chimeric antigen receptors that can be used to direct immunocompetent cells to tumors, which results in anti-tumor immunity. In addition, gene therapy treatments for the bleeding disorder, hemophilia, have been developed and are advancing to clinical trials, with a hope of curing the disease.
Grant Number | Title |
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5K08HL141635-05 | Targeted non-genotoxic hematopoietic stem cell transplant conditioning approach |
Title/Journal | Authors | Publication Date |
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Proceedings of the Think Tank for Osteosarcoma Medical Advisory Board. Anticancer research |
SP Chawla, B VAN Tine, N Federman, J Schwab, R Jones, V Subbiah, NS Chawla, N Afshar, W Hoos, N Feldman, HT Spencer, W Swaney, EM Gordon | 07/01/2024 |
Journal of thrombosis and haemostasis : JTH |
CW Coyle, KA Knight, HC Brown, SN George, G Denning, GM Branella, KC Childers, PC Spiegel, HT Spencer, CB Doering | 03/01/2024 |
Directing the migration of serum-free, ex vivo-expanded Vγ9Vδ2 T cells. Frontiers in immunology |
KK Parwani, GM Branella, RE Burnham, AJ Burnham, AYS Bustamante, EM Foppiani, KA Knight, BG Petrich, EM Horwitz, CB Doering, HT Spencer | 01/01/2024 |
Nature communications |
M Rodriguez, B Trevisan, RM Ramamurthy, SK George, J Diaz, J Alexander, D Meares, DJ Schwahn, DR Quilici, J Figueroa, M Gautreaux, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada | 07/14/2023 |
Cell reports. Medicine |
JY Lee, HC Jonus, A Sadanand, GM Branella, V Maximov, S Suttapitugsakul, MJ Schniederjan, J Shim, A Ho, KK Parwani, A Fedanov, AA Pilgrim, JA Silva, RW Schnepp, CB Doering, R Wu, HT Spencer, KC Goldsmith | 06/20/2023 |
Molecular therapy oncolytics |
SA Becker, BG Petrich, B Yu, KA Knight, HC Brown, SS Raikar, CB Doering, HT Spencer | 06/15/2023 |
Frontiers in immunology |
GM Branella, JY Lee, J Okalova, KK Parwani, JS Alexander, RF Arthuzo, A Fedanov, B Yu, D McCarty, HC Brown, S Chandrakasan, BG Petrich, CB Doering, HT Spencer | 01/01/2023 |
Blood advances |
KC Childers, SC Peters, P Lollar, HT Spencer, CB Doering, PC Spiegel | 06/14/2022 |
Gene therapy |
JT Zoine, C Prince, JY Story, GM Branella, AM Lytle, A Fedanov, JS Alexander, CC Porter, CB Doering, HT Spencer, S Chandrakasan | 05/01/2022 |
Blood advances |
TS Lundgren, G Denning, SR Stowell, HT Spencer, CB Doering | 04/26/2022 |
Blood |
CR Funk, S Wang, KZ Chen, A Waller, A Sharma, CL Edgar, VA Gupta, S Chandrakasan, JT Zoine, A Fedanov, SS Raikar, JL Koff, CR Flowers, S Coma, JA Pachter, S Ravindranathan, HT Spencer, M Shanmugam, EK Waller | 01/27/2022 |
Frontiers in immunology |
RM Ramamurthy, M Rodriguez, HC Ainsworth, J Shields, D Meares, C Bishop, A Farland, CD Langefeld, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada | 01/01/2022 |
Oncoimmunology |
HC Jonus, RE Burnham, A Ho, AA Pilgrim, J Shim, CB Doering, HT Spencer, KC Goldsmith | 01/01/2022 |
Cells |
GM Branella, HT Spencer | 12/22/2021 |
Molecular therapy. Methods & clinical development |
SRP Kumar, J Xie, S Hu, J Ko, Q Huang, HC Brown, A Srivastava, DM Markusic, CB Doering, HT Spencer, A Srivastava, G Gao, RW Herzog | 12/10/2021 |
Scientific reports |
LS Lamb, L Pereboeva, S Youngblood, GY Gillespie, LB Nabors, JM Markert, A Dasgupta, C Langford, HT Spencer | 10/26/2021 |
Blood advances |
KA Knight, CW Coyle, CE Radford, ET Parker, A Fedanov, JM Shields, F Szlam, A Purchel, M Chen, G Denning, RM Sniecinski, P Lollar, HT Spencer, EA Gaucher, CB Doering | 09/14/2021 |
Molecular therapy. Methods & clinical development |
AL Russell, C Prince, TS Lundgren, KA Knight, G Denning, JS Alexander, JT Zoine, HT Spencer, S Chandrakasan, CB Doering | 06/11/2021 |
Blood |
JS Gish, L Jarvis, KC Childers, SC Peters, CS Garrels, IW Smith, HT Spencer, CB Doering, P Lollar, PC Spiegel | 05/27/2021 |
Cryobiology |
RE Burnham, D Tope, G Branella, E Williams, CB Doering, HT Spencer | 04/01/2021 |
Molecular coevolution of coagulation factor VIII and von Willebrand factor. Blood advances |
PM Zakas, CW Coyle, A Brehm, M Bayer, B Solecka-Witulska, CE Radford, C Brown, K Nesbitt, C Dwyer, C Kannicht, HT Spencer, EA Gaucher, CB Doering, D Lillicrap | 02/09/2021 |
Current stem cell reports |
A Dasgupta, K Herzegh, HT Spencer, C Doering, E Day, WP Swaney | 01/01/2021 |
Cytotherapy |
JY Story, JT Zoine, RE Burnham, JAG Hamilton, HT Spencer, CB Doering, SS Raikar | 01/01/2021 |
Effects of Shear Stress on Production of FVIII and vWF in a Cell-Based Therapeutic for Hemophilia A. Frontiers in bioengineering and biotechnology |
B Trevisan, A Morsi, J Aleman, M Rodriguez, J Shields, D Meares, AM Farland, CB Doering, HT Spencer, A Atala, A Skardal, CD Porada, G Almeida-Porada | 01/01/2021 |
Frontiers in cell and developmental biology |
C Stem, C Rodman, RM Ramamurthy, S George, D Meares, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada | 01/01/2021 |
Frontiers in immunology |
EK Ronayne, SC Peters, JS Gish, C Wilson, HT Spencer, CB Doering, P Lollar, PC Spiegel, KC Childers | 01/01/2021 |
Development of a Clinical Candidate AAV3 Vector for Gene Therapy of Hemophilia B. Human gene therapy |
HC Brown, CB Doering, RW Herzog, C Ling, DM Markusic, HT Spencer, A Srivastava, A Srivastava | 10/01/2020 |
Molecular therapy oncolytics |
LC Fleischer, SA Becker, RE Ryan, A Fedanov, CB Doering, HT Spencer | 09/25/2020 |
Defining the Optimal FVIII Transgene for Placental Cell-Based Gene Therapy to Treat Hemophilia A. Molecular therapy. Methods & clinical development |
N El-Akabawy, M Rodriguez, R Ramamurthy, A Rabah, B Trevisan, A Morsi, S George, J Shields, D Meares, A Farland, A Atala, CB Doering, HT Spencer, CD Porada, G Almeida-Porada | 06/12/2020 |
Human gene therapy |
SE Takushi, NY Paik, A Fedanov, C Prince, CB Doering, HT Spencer, S Chandrakasan | 06/01/2020 |
The Immune Response to the fVIII Gene Therapy in Preclinical Models. Frontiers in immunology |
SR Patel, TS Lundgren, HT Spencer, CB Doering | 01/01/2020 |
Frontiers in medicine |
RE Burnham, JT Zoine, JY Story, SN Garimalla, G Gibson, A Rae, E Williams, L Bixby, D Archer, CB Doering, HT Spencer | 01/01/2020 |
Journal of thrombosis and haemostasis : JTH |
IW Smith, AE d'Aquino, CW Coyle, A Fedanov, ET Parker, G Denning, HT Spencer, P Lollar, CB Doering, PC Spiegel | 01/01/2020 |
Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions. Journal of hematology & oncology |
LC Fleischer, HT Spencer, SS Raikar | 12/29/2019 |
Oncoimmunology |
JT Zoine, KA Knight, LC Fleischer, KS Sutton, KC Goldsmith, CB Doering, HT Spencer | 01/01/2019 |
Human gene therapy |
CB Doering, G Denning, JE Shields, EJ Fine, ET Parker, A Srivastava, P Lollar, HT Spencer | 10/01/2018 |
Target-Cell-Directed Bioengineering Approaches for Gene Therapy of Hemophilia A. Molecular therapy. Methods & clinical development |
HC Brown, PM Zakas, SN George, ET Parker, HT Spencer, CB Doering | 06/15/2018 |
Hurdles Associated with the Translational Use of Genetically Modified Cells. Current stem cell reports |
SS Raikar, HT Spencer | 03/01/2018 |
Blood advances |
CT Petersen, M Hassan, AB Morris, J Jeffery, K Lee, N Jagirdar, AD Staton, SS Raikar, HT Spencer, T Sulchek, CR Flowers, EK Waller | 02/13/2018 |
Oncoimmunology |
SS Raikar, LC Fleischer, R Moot, A Fedanov, NY Paik, KA Knight, CB Doering, HT Spencer | 01/01/2018 |
Microfluidic Transduction Harnesses Mass Transport Principles to Enhance Gene Transfer Efficiency. Molecular therapy : the journal of the American Society of Gene Therapy |
R Tran, DR Myers, G Denning, JE Shields, AM Lytle, H Alrowais, Y Qiu, Y Sakurai, WC Li, O Brand, JM Le Doux, HT Spencer, CB Doering, WA Lam | 10/04/2017 |
Enhancing the pharmaceutical properties of protein drugs by ancestral sequence reconstruction. Nature biotechnology |
PM Zakas, HC Brown, K Knight, SL Meeks, HT Spencer, EA Gaucher, CB Doering | 01/01/2017 |
Bioengineering and serum free expansion of blood-derived γδ T cells. Cytotherapy |
KS Sutton, A Dasgupta, D McCarty, CB Doering, HT Spencer | 07/01/2016 |
Molecular therapy oncolytics |
R Moot, SS Raikar, L Fleischer, M Querrey, DE Tylawsky, H Nakahara, CB Doering, HT Spencer | 01/01/2016 |
Molecular therapy. Methods & clinical development |
AM Lytle, HC Brown, NY Paik, KA Knight, JF Wright, HT Spencer, CB Doering | 01/01/2016 |
Replacing bad (F)actors: hemophilia. Hematology. American Society of Hematology. Education Program |
CB Doering, HT Spencer | 12/05/2014 |
Simplified prototyping of perfusable polystyrene microfluidics. Biomicrofluidics |
R Tran, B Ahn, DR Myers, Y Qiu, Y Sakurai, R Moot, E Mihevc, H Trent Spencer, C Doering, W A Lam | 07/01/2014 |
Molecular therapy. Methods & clinical development |
HC Brown, JF Wright, S Zhou, AM Lytle, JE Shields, HT Spencer, CB Doering | 01/01/2014 |
Human gene therapy methods |
L Baranyi, CB Doering, G Denning, RE Gautney, KT Harris, HT Spencer, A Roy, H Zayed, B Dropulic | 08/01/2013 |
PloS one |
LS Lamb, J Bowersock, A Dasgupta, GY Gillespie, Y Su, A Johnson, HT Spencer | 01/01/2013 |
Human gene therapy |
A Dasgupta, JE Shields, HT Spencer | 07/01/2012 |
Development and characterization of recombinant ovine coagulation factor VIII. PloS one |
PM Zakas, B Gangadharan, G Almeida-Porada, CD Porada, HT Spencer, CB Doering | 01/01/2012 |
Experimental hematology |
CD Porada, C Sanada, CJ Kuo, E Colletti, W Mandeville, J Hasenau, ED Zanjani, R Moot, C Doering, HT Spencer, G Almeida-Porada | 12/01/2011 |
Engineered Hematopoietic Stem Cells as Therapeutics for Hemophilia A. Journal of genetic syndromes & gene therapy |
PM Zakas, HT Spencer, CB Doering | 11/16/2011 |
Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII. Molecular therapy : the journal of the American Society of Gene Therapy |
HT Spencer, G Denning, RE Gautney, B Dropulic, AJ Roy, L Baranyi, B Gangadharan, ET Parker, P Lollar, CB Doering | 02/01/2011 |
Delivery of nucleic acid therapeutics by genetically engineered hematopoietic stem cells. Advanced drug delivery reviews |
CB Doering, D Archer, HT Spencer | 09/30/2010 |
The journal of gene medicine |
LM Ide, NN Iwakoshi, B Gangadharan, S Jobe, R Moot, D McCarty, CB Doering, HT Spencer | 04/01/2010 |
BMC biotechnology |
JL Taylor, P Rohatgi, HT Spencer, DF Doyle, B Azizi | 02/18/2010 |
Biochemical and biophysical research communications |
A Dasgupta, D McCarty, HT Spencer | 01/01/2010 |
Advancements in gene transfer-based therapy for hemophilia A. Expert review of hematology |
CB Doering, HT Spencer | 12/01/2009 |
Molecular therapy : the journal of the American Society of Gene Therapy |
CB Doering, G Denning, K Dooriss, B Gangadharan, JM Johnston, KW Kerstann, DA McCarty, HT Spencer | 07/01/2009 |
Human gene therapy |
KL Dooriss, G Denning, B Gangadharan, EH Javazon, DA McCarty, HT Spencer, CB Doering | 05/01/2009 |
Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells. Methods in molecular biology (Clifton, N.J.) |
LM Ide, E Javazon, HT Spencer | 01/01/2008 |