Eric Sundberg, PhD

Research Program

Cancer Immunology
Phone Number

404-712-7301
Email Address

eric.sundberg@emory.edu

Biography

Eric J. Sundberg, PhD, is a professor and chair in the Department of Biochemistry at Emory University School of Medicine. Dr. Sundberg is a member of the Cancer Immunology Research Program at Winship Cancer Institute.

Education

Dr. Sundberg earned his PhD in the Inter-departmental Biological Sciences Program at Northwestern University. He completed a postdoctoral fellowship at the Center for Advanced Research in Biotechnology-University of Maryland Biotechnology Institute (now the Institute for Bioscience and Biotechnology at the University of Maryland.)

Titles & Roles

Professor and Chair, Department of Biochemistry

Emory University School of Medicine

Research

Dr. Sundberg's research program leverages expertise in structural biology, molecular biophysics and protein engineering to define the molecular bases of infectious diseases and to develop novel protein therapeutics.

Grants

View Grants

Grant Number	Title
1R01AI149297-01	Rationalizing glycoengineering strategies for immunotherapeutic antibodies
1R21AI175869-01	Engineering mono-fucosylated IgGs to fine-tune antibody-mediated effector functions
5R01AI149297-02	Rationalizing glycoengineering strategies for immunotherapeutic antibodies
5R01AI149297-03	Rationalizing glycoengineering strategies for immunotherapeutic antibodies
5R01AI149297-04	Rationalizing glycoengineering strategies for immunotherapeutic antibodies
5R01AI149297-05	Rationalizing glycoengineering strategies for immunotherapeutic antibodies
5R21AI175869-02	Engineering mono-fucosylated IgGs to fine-tune antibody-mediated effector functions

Publications

Title/Journal	Authors	Publication Date
Potent efficacy of an IgG-specific endoglycosidase against IgG-mediated pathologies. Cell	DE Sastre, S Bournazos, J Du, EJ Boder, JE Edgar, T Azzam, N Sultana, M Huliciak, M Flowers, L Yoza, T Xu, TA Chernova, JV Ravetch, EJ Sundberg	11/27/2024
Human gut microbes express functionally distinct endoglycosidases to metabolize the same N-glycan substrate. Nature communications	DE Sastre, N Sultana, M V A S Navarro, M Huliciak, J Du, JO Cifuente, M Flowers, X Liu, P Lollar, B Trastoy, ME Guerin, EJ Sundberg	06/15/2024
Antibodies targeting the shared cytokine receptor IL-1 receptor accessory protein invoke distinct mechanisms to block all cytokine signaling. Cell reports	JK Fields, EJ Gyllenbäck, M Bogacz, J Obi, GS Birkedal, K Sjöström, K Maravillas, C Grönberg, S Rattik, K Kihn, M Flowers, AK Smith, N Hansen, T Fioretos, C Huyhn, D Liberg, D Deredge, EJ Sundberg	05/28/2024
Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers. Science advances	T Azzam, JJ Du, MW Flowers, AV Ali, JC Hunn, N Vijayvargiya, R Knagaram, M Bogacz, KE Maravillas, DE Sastre, JK Fields, A Mirzaei, BG Pierce, EJ Sundberg	04/12/2024
Modulating antibody effector functions by Fc glycoengineering. Biotechnology advances	M García-Alija, B van Moer, DE Sastre, T Azzam, JJ Du, B Trastoy, N Callewaert, EJ Sundberg, ME Guerin	10/01/2023
Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody. Nature communications	A Gupta, KS Kao, R Yamin, DA Oren, Y Goldgur, J Du, P Lollar, EJ Sundberg, JV Ravetch	05/18/2023
Croquemort elicits activation of the immune deficiency pathway in ticks. Proceedings of the National Academy of Sciences of the United States of America	AJ O'Neal, N Singh, A Rolandelli, HJ Laukaitis, X Wang, DK Shaw, BD Young, S Narasimhan, S Dutta, GA Snyder, S Samaddar, L Marnin, LR Butler, MT Mendes, FE Cabrera Paz, LM Valencia, EJ Sundberg, E Fikrig, U Pal, DJ Weber, JHF Pedra	05/16/2023
An unbroken network of interactions connecting flagellin domains is required for motility in viscous environments. PLoS pathogens	M Nedeljković, MAB Kreutzberger, S Postel, D Bonsor, Y Xing, N Jacob, WJ Schuler, EH Egelman, EJ Sundberg	05/01/2023
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nature communications	B Trastoy, JJ Du, JO Cifuente, L Rudolph, M García-Alija, EH Klontz, D Deredge, N Sultana, CG Huynh, MW Flowers, C Li, DE Sastre, LX Wang, F Corzana, A Mallagaray, EJ Sundberg, ME Guerin	03/27/2023
Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum. Nature chemical biology	RL Cordeiro, CR Santos, MN Domingues, TB Lima, RAS Pirolla, MAB Morais, FM Colombari, RY Miyamoto, GF Persinoti, AC Borges, MA de Farias, F Stoffel, C Li, FC Gozzo, M van Heel, ME Guerin, EJ Sundberg, LX Wang, RV Portugal, PO Giuseppe, MT Murakami	02/01/2023
Mechanism of glycoform specificity and protection against antibody dependent enhancement by an anti-afucosylated IgG nanobody. bioRxiv : the preprint server for biology	A Gupta, K Kao, R Yamin, DA Oren, Y Goldgur, J Du, P Lollar, EJ Sundberg, JV Ravetch	01/24/2023
Mass Spectrometry-Based Methods to Determine the Substrate Specificities and Kinetics of N-Linked Glycan Hydrolysis by Endo-β-N-Acetylglucosaminidases. Methods in molecular biology (Clifton, N.J.)	JJ Du, D Sastre, B Trastoy, B Roberts, D Deredge, EH Klontz, MW Flowers, N Sultana, ME Guerin, EJ Sundberg	01/01/2023
The role of adjuvants in overcoming antibacterial resistance due to enzymatic drug modification. RSC medicinal chemistry	C El-Khoury, E Mansour, Y Yuliandra, F Lai, BA Hawkins, JJ Du, EJ Sundberg, N Sluis-Cremer, DE Hibbs, PW Groundwater	11/16/2022
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE. Nature communications	M García-Alija, JJ Du, I Ordóñez, A Diz-Vallenilla, A Moraleda-Montoya, N Sultana, CG Huynh, C Li, TC Donahue, LX Wang, B Trastoy, EJ Sundberg, ME Guerin	03/03/2022
Sculpting therapeutic monoclonal antibody N-glycans using endoglycosidases. Current opinion in structural biology	B Trastoy, JJ Du, M García-Alija, C Li, EH Klontz, LX Wang, EJ Sundberg, ME Guerin	02/01/2022
Molecular Determinants of Filament Capping Proteins Required for the Formation of Functional Flagella in Gram-Negative Bacteria. Biomolecules	M Nedeljković, S Postel, BG Pierce, EJ Sundberg	09/22/2021
GH18 endo-β-N-acetylglucosaminidases use distinct mechanisms to process hybrid-type N-linked glycans. The Journal of biological chemistry	B Trastoy, JJ Du, C Li, M García-Alija, EH Klontz, BR Roberts, TC Donahue, LX Wang, EJ Sundberg, ME Guerin	08/01/2021
Biophysicists' continued outstanding response to COVID-19. Biophysical journal	T Schlick, EJ Sundberg, SJ Schroeder, MM Babu	07/20/2021
Bacterial Flagellar Filament: A Supramolecular Multifunctional Nanostructure. International journal of molecular sciences	M Nedeljković, DE Sastre, EJ Sundberg	07/14/2021
Insights into substrate recognition and specificity for IgG by Endoglycosidase S2. PLoS computational biology	AH Aytenfisu, D Deredge, EH Klontz, J Du, EJ Sundberg, AD MacKerell	07/01/2021
Bacterial protein domains with a novel Ig-like fold target human CEACAM receptors. The EMBO journal	NM van Sorge, DA Bonsor, L Deng, E Lindahl, V Schmitt, M Lyndin, A Schmidt, OR Nilsson, J Brizuela, E Boero, EJ Sundberg, JAG van Strijp, KS Doran, BB Singer, G Lindahl, AJ McCarthy	04/01/2021
Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium. Communications biology	AK Gandhi, ZJ Sun, WM Kim, YH Huang, Y Kondo, DA Bonsor, EJ Sundberg, G Wagner, VK Kuchroo, GA Petsko, RS Blumberg	03/19/2021
Biophysicists' outstanding response to Covid-19. Biophysical journal	T Schlick, EJ Sundberg, SJ Schroeder, MM Babu	03/16/2021
Congressional Budget Responses to the Pandemic: Fund Health Care, Not Warfare. American journal of public health	J King, D Goldenberg, G Goldstein, W Hartung, C Royer, E Sundberg, C van der Ziel, M Van Elzakker, R Roberts	02/01/2021
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor. Frontiers in immunology	JK Fields, K Kihn, GS Birkedal, EH Klontz, K Sjöström, S Günther, R Beadenkopf, G Forsberg, D Liberg, GA Snyder, D Deredge, EJ Sundberg	01/01/2021