Yong Wan, PhD
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Research Program
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Phone Number
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Email Address
Biography
Yong Wan, PhD, is a School of Medicine Endowed Faculty Professor in the Department of Pharmacology and Chemical Biology with a secondary appointment as professor in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Wan, a leading expert in posttranslational modifications and cancer biology, serves as director for basic research for the Glenn Family Breast Center at Winship Cancer Institute of Emory University.
Dr. Wan joined Emory from the Feinberg School of Medicine at Northwestern University in Chicago. There, he served as professor of obstetrics and gynecology in the Division of Reproductive Science in Medicine, professor of pharmacology, and co-director of the Breast Cancer Program for the Robert Lurie Comprehensive Cancer Center. Prior to joining Northwestern, he served on the faculty of the Department of Cell Biology at the University of Pittsburgh School of Medicine and Hillman Comprehensive Cancer Center.
Education
Dr. Wan received his PhD from Cornell University in Ithaca, New York. He completed his postdoctoral training as a Helen Hay Whitney fellow at Harvard Medical School in Cambridge, Massachusetts.
Titles & Roles
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SOM Endowed Professor, Department of Pharmacology and Chemical BiologyEmory University School of Medicine
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Professor, Department of Hematology and Medical OncologyEmory University School of Medicine
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Director for Basic Research, Glenn Family Breast CenterWinship Cancer Institute of Emory University
Research
Dr. Wan studies mechanisms of breast carcinogenesis and identifies novel targets for therapeutic development. Particularly, he seeks address how defects in the ubiquitin-proteasome system and other posttranslational modifiers such as protein methyltransferase, poly (ADP-ribose) polymerase and glycosyltransferase would result in deregulated tumor immune checkpoint function, genomic instability, and aberrant signaling that predispose otherwise normal cells to become cancerous tumor cells or promote cancer progression and metastasis.
Recent studies led by Dr. Wan have identified promising new strategies to improve the efficacy of immunotherapy in patients with triple-negative breast cancer.
Grants
| Grant Number | Title |
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| 5R01CA250110-04 | Targeting Posttranslational Modifications in Breast Carcinogenesis |
| 5R01CA250110-05 | Targeting Posttranslational Modifications in Breast Carcinogenesis |
| 5R01CA258765-03 | Targeting posttranslational modifications of B7-H4 in carcinogenesis and therapy |
| 5R01CA258765-04 | Targeting posttranslational modifications of B7-H4 in carcinogenesis and therapy |
| 5R01CA258857-03 | Targeting posttranslational modifications of CD73 in TNBCs |
| 5R01CA258857-04 | Targeting posttranslational modifications of CD73 in TNBCs |
| 7R01CA258765-02 | Targeting posttranslational modifications of B7-H4 in carcinogenesis and therapy |
| 7R01CA258857-02 | Targeting posttranslational modifications of CD73 in TNBCs |
Publications
| Title/Journal | Authors | Publication Date |
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The Journal of clinical investigation |
J Ahn, P Xie, S Chen, G Shi, J Fan, M Zhang, H Tang, AR Zuckerman, D Fang, Y Wan, TM Kuzel, Y Zhang, B Zhang | 06/02/2025 |
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MGAT1-Guided complex N-Glycans on CD73 regulate immune evasion in triple-negative breast cancer. Nature communications |
JJ Chi, P Xie, MH Cheng, Y Zhu, X Cui, J Watson, L Zeng, A Uddin, H Nguyen, L Li, K Moremen, A Reedy, M Wyatt, A Marcus, M Dai, CM Paulos, M Cristofanilli, WJ Gradishar, S Zhao, K Kalinsky, MC Hung, I Bahar, B Zhang, Y Wan | 04/15/2025 |
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
X Cui, Y Zhu, L Zeng, M Zhang, A Uddin, TW Gillespie, LE McCullough, S Zhao, MA Torres, Y Wan | 03/01/2025 |
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Ten-Step Total Synthesis of (±)-Phaeocaulisin A Enabled by Cyclopropanol Ring-Opening Carbonylation. Journal of the American Chemical Society |
C Liu, M Zhang, L Zeng, Y Wan, M Dai | 11/27/2024 |
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Advanced science (Weinheim, Baden-Wurttemberg, Germany) |
L Zeng, Y Zhu, X Cui, J Chi, A Uddin, Z Zhou, X Song, M Dai, M Cristofanilli, K Kalinsky, Y Wan | 10/01/2024 |
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The Journal of clinical investigation |
Y Zhu, A Banerjee, P Xie, AA Ivanov, A Uddin, Q Jiao, JJ Chi, L Zeng, JY Lee, Y Xue, X Lu, M Cristofanilli, WJ Gradishar, CJ Henry, TW Gillespie, MA Bhave, K Kalinsky, H Fu, I Bahar, B Zhang, Y Wan | 03/26/2024 |
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The Journal of clinical investigation |
S Chen, J Fan, P Xie, J Ahn, M Fernandez, LK Billingham, J Miska, JD Wu, DA Wainwright, D Fang, JA Sosman, Y Wan, Y Zhang, NS Chandel, B Zhang | 03/05/2024 |
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New insights into KLFs and SOXs in cancer pathogenesis, stemness, and therapy. Seminars in cancer biology |
L Zeng, Y Zhu, CS Moreno, Y Wan | 05/01/2023 |
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Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity. Science advances |
Z Fu, S Chen, Y Zhu, D Zhang, P Xie, Q Jiao, J Chi, S Xu, Y Xue, X Lu, X Song, M Cristofanilli, WJ Gradishar, K Kalinsky, Y Yin, B Zhang, Y Wan | 01/06/2023 |
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CDC20-Mediated hnRNPU Ubiquitination Regulates Chromatin Condensation and Anti-Cancer Drug Response. Cancers |
C Wavelet-Vermuse, O Odnokoz, Y Xue, X Lu, M Cristofanilli, Y Wan | 07/31/2022 |
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Ductal Carcinoma In Situ of Breast: From Molecular Etiology to Therapeutic Management. Endocrinology |
SL Hophan, O Odnokoz, H Liu, Y Luo, S Khan, W Gradishar, Z Zhou, S Badve, MA Torres, Y Wan | 04/01/2022 |