David Yu, MD, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-616-3957

Biography

David S. Yu, MD, PhD, is the Jerome Landry MD Chair of Cancer Biology and a professor in the Department of Radiation Oncology at Emory University School of Medicine. He also serves as director of the Division of Cancer Biology and Vice Chair for Biology Research.

A board certified radiation oncologist, Dr. Yu specializes in the treatment of head and neck cancer, breast cancer, and lung cancer. As a Georgia Cancer Coalition Distinguished Cancer Clinician and Scientist, Dr. Yu's goal is to translate insights gained from interactions with his patients and his research in the laboratory to innovative therapies to improve the quality of care for patients with cancer.

Dr. Yu is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University. He is a member of the Emory Graduate Programs in Cancer Biology and Genetics and Molecular Biology, and the Emory MD/PhD Program.

Education

Dr. Yu received his MD from the University of Texas at Southwestern Medical School and PhD from the University of Cambridge prior to completing residency training in Radiation Oncology at Vanderbilt University Medical Center. During his residency training, Dr. Yu was an American Board of Radiology Holman Research Pathway fellow.

Titles & Roles

Jerome Landry MD Chair of Cancer Biology and Professor, Department of Radiation Oncology

Emory University School of Medicine
Director, Division of Cancer Biology, Department of Radiation Oncology

Emory University School of Medicine
Vice Chair for Biology Research, Department of Radiation Oncology

Emory University School of Medicine

Professional Memberships

Dr. Yu is a member of the ASTRO Radiation and Cancer Biology Committee Research Council, ASTRO Research Evaluation Committee Research Council, American Society for Clinical Investigation, American Society of Clinical Oncology, American Association for Cancer Research, Radiation Research Society and Radiological Society of North America among others.

Research

Dr. Yu is actively engaged in both clinical and science research, including, understanding how cells respond to replication stress and how to utilize this knowledge for improvements in cancer diagnosis and treatment.

In his laboratory at Emory, Dr. Yu is examining the role of sirtuin deacetylases, and more generally the acetylome, in orchestrating the replication stress response. He is working to identify novel components of the replication stress response, which mediate sensitivity of cancer cells to DNA damaging agents, utilizing high throughput loss of function genetic screens. His lab is also focused on understanding mechanistically how novel replication stress response proteins function using cell biological, genetic, and biochemical approaches to define the functions of these proteins. He hopes to translate insights gained from mechanistic analyses to improvements in the clinic. By exploiting defects in the replication stress response, he hopes to utilize novel replication stress response proteins as biomarkers for clinical response and outcome to specific cancer treatments and as novel therapeutic targets to personalize cancer therapy.

Grants

View Grants

Grant Number	Title
1R01CA254403-01	Elucidating SAMHD1 in DNA Double-Strand Break Repair
1T32CA275777-01A1	T32 Training Program in Cancer Biology
1U54CA274513-01	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
1U54CA274513-01	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
1U54CA274513-01	P3: Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint BlockadeýSUBAWARD
3R01CA254403-04S1	Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement)
3R01CA254403-04S2	Elucidating SAMHD1 in DNA Double-Strand Break Repair (Supplement)
3R01CA254403-05S1	Elucidating SAMHD1 in DNA Double-Strand Break Repair
3R01CA254403-05S2	Elucidating SAMHD1 in DNA Double-Strand Break Repair
3U54CA274513-02S1	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
3U54CA274513-02S2	Project 3 Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint Blockade
3U54CA274513-03S1	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
3U54CA274513-03S2	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
5R01CA178999-10	Mechanisms of SIRT2 Function in the DNA Damage Response
5R01CA254403-02	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-03	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-04	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5R01CA254403-05	Elucidating SAMHD1 in DNA Double-Strand Break Repair
5T32CA275777-02	T32 Training Program in Cancer Biology
5U54CA274513-02	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
5U54CA274513-02	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
5U54CA274513-02	P3: Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint BlockadeýSUBAWARD
5U54CA274513-03	Genomic and Microenvironmental Determinants, Temporal Dynamics, and Treatment Efficacy of Radiation-Based Combination Therapies
5U54CA274513-03	P3: Molecular Mechanisms Underlying Therapy Response to Radiation and Immune Checkpoint BlockadeýSUBAWARD

Publications

Dr. Yu has authored a number of publications in high impact journals, including Nature, Cell, Molecular Cell, Cell Reports, and PNAS. He is associate editor of International Journal of Radiation Biology.

Title/Journal	Authors	Publication Date
MRI super-resolution reconstruction using efficient diffusion probabilistic model with residual shifting. Physics in medicine and biology	M Safari, S Wang, Z Eidex, Q Li, RLJ Qiu, EH Middlebrooks, DS Yu, X Yang	06/03/2025
MRI super-resolution reconstruction using efficient diffusion probabilistic model with residual shifting. ArXiv	M Safari, S Wang, Z Eidex, Q Li, RLJ Qiu, EH Middlebrooks, DS Yu, X Yang	04/26/2025
Combination radiation and αPD-L1 enhance tumor control by stimulating CD8+ PD-1+ TCF-1+ T cells in the tumor-draining lymph node. Nature communications	Y Shen, E Connolly, M Aiello, C Zhou, P Chappa, H Song, P Tippitak, T Clark, M Cardenas, N Prokhnevska, A Mariniello, I De Bruyker, MS Pagadala, VR Dhere, S Rafiq, AH Kesarwala, A Orthwein, SN Thomas, SL Zhang, MK Khan, JB Dixon, GB Lesinski, MC Lowe, H Kissick, DS Yu, CM Paulos, NC Schmitt, ZS Buchwald	04/14/2025
T1-contrast enhanced MRI generation from multi-parametric MRI for glioma patients with latent tumor conditioning. Medical physics	Z Eidex, M Safari, RLJ Qiu, DS Yu, HK Shu, H Mao, X Yang	04/01/2025
Unsupervised Bayesian generation of synthetic CT from CBCT using patient-specific score-based prior. Medical physics	J Peng, Y Gao, CW Chang, R Qiu, T Wang, A Kesarwala, K Yang, J Scott, D Yu, X Yang	04/01/2025
Triad: Vision Foundation Model for 3D Magnetic Resonance Imaging. Research square	S Wang, M Safari, Q Li, CW Chang, RL Qiu, J Roper, DS Yu, X Yang	03/10/2025
Automatic medical imaging segmentation via self-supervising large-scale convolutional neural networks. Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology	Y Li, JF Wynne, Y Wu, RLJ Qiu, S Tian, T Wang, PR Patel, DS Yu, X Yang	03/01/2025
A Physics-Informed Deep Learning Model for MRI Brain Motion Correction. ArXiv	M Safari, S Wang, Z Eidex, R Qiu, CW Chang, DS Yu, X Yang	02/13/2025
Exploration of an adaptive proton therapy strategy using CBCT with the concept of digital twins. Physics in medicine and biology	CW Chang, Z Tian, RLJ Qiu, H Scott Mcginnis, D Bohannon, P Patel, Y Wang, DS Yu, SA Patel, J Zhou, X Yang	01/17/2025
Optimization-Based Image Reconstruction Regularized with Inter-Spectral Structural Similarity for Limited-Angle Dual-Energy Cone-Beam CT. ArXiv	J Peng, T Wang, H Xie, RLJ Qiu, CW Chang, J Roper, DS Yu, X Tang, X Yang	12/18/2024
Feasibility study of modularized pin ridge filter implementation in proton FLASH planning for liver stereotactic ablative body radiotherapy. Physics in medicine and biology	C Ma, X Yang, J Setianegara, Y Wang, Y Gao, D Yu, P Patel, J Zhou	12/03/2024
Loss of tet methyl cytosine dioxygenase 3 (TET3) enhances cardiac fibrosis via modulating the DNA damage repair response. Clinical epigenetics	SK Rath, G Nyamsuren, B Tampe, DS Yu, MS Hulshoff, D Schlösser, S Maamari, M Zeisberg, EM Zeisberg	08/27/2024
PD-L1 deglycosylation promotes its nuclear translocation and accelerates DNA double-strand-break repair in cancer. Nature communications	Z Shu, B Dwivedi, JM Switchenko, DS Yu, X Deng	08/09/2024
Unsupervised Bayesian Generation of Synthetic CT from CBCT Using Patient-Specific Score-Based Prior. ArXiv	J Peng, Y Gao, CW Chang, R Qiu, T Wang, A Kesarwala, K Yang, J Scott, D Yu, X Yang	06/21/2024
A retrospective study on the investigation of potential dosimetric benefits of online adaptive proton therapy for head and neck cancer. Journal of applied clinical medical physics	CW Chang, D Bohannon, Z Tian, Y Wang, MW Mcdonald, DS Yu, T Liu, J Zhou, X Yang	05/01/2024
Streamlined pin-ridge-filter design for single-energy proton FLASH planning. Medical physics	C Ma, J Zhou, CW Chang, Y Wang, PR Patel, DS Yu, S Tian, X Yang	04/01/2024
Synthetic CT generation from MRI using 3D transformer-based denoising diffusion model. Medical physics	S Pan, E Abouei, J Wynne, CW Chang, T Wang, RLJ Qiu, Y Li, J Peng, J Roper, P Patel, DS Yu, H Mao, X Yang	04/01/2024
Radiation and anti-PD-L1 synergize by stimulating a stem-like T cell population in the tumor-draining lymph node. Research square	Y Shen, E Connolly, M Aiello, C Zhou, P Chappa, H Song, P Tippitak, T Clark, M Cardenas, N Prokhnevska, A Mariniello, MS Pagadala, VR Dhere, S Rafiq, AH Kesarwala, A Orthwein, SN Thomas, MK Khan, J Brandon Dixon, GB Lesinski, MC Lowe, H Kissick, DS Yu, CM Paulos, NC Schmitt, ZS Buchwald	03/06/2024
CBCT-Based synthetic CT image generation using conditional denoising diffusion probabilistic model. Medical physics	J Peng, RLJ Qiu, JF Wynne, CW Chang, S Pan, T Wang, J Roper, T Liu, PR Patel, DS Yu, X Yang	03/01/2024
SAMHD1 expression contributes to doxorubicin resistance and predicts survival outcomes in diffuse large B-cell lymphoma patients. NAR cancer	W Daddacha, D Monroe, AJ Schlafstein, AE Withers, EB Thompson, D Danelia, NC Luong, F Sesay, SK Rath, ER Usoro, ME Essien, AT Jung, JG Jiang, J Hu, B Mahboubi, A Williams, JE Steinbeck, X Yang, ZS Buchwald, WS Dynan, JM Switchenko, B Kim, MK Khan, DL Jaye, DS Yu	03/01/2024
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops). The Journal of biological chemistry	JL de Amorim, SW Leung, R Haji-Seyed-Javadi, Y Hou, DS Yu, H Ghalei, S Khoshnevis, B Yao, AH Corbett	02/01/2024
ATR signaling controls the bystander responses of human chondrosarcoma cells by promoting RAD51-dependent DNA repair. International journal of radiation biology	NC Luong, H Kawamura, H Ikeda, RT Roppongi, A Shibata, J Hu, JG Jiang, DS Yu, KD Held	01/01/2024
Streamlined Pin-Ridge-Filter Design for Single-energy Proton FLASH Planning. ArXiv	C Ma, J Zhou, CW Chang, Y Wang, PR Patel, DS Yu, S Tian, X Yang	10/03/2023
Estimating Potential Benefits of Online Adaptive Proton Therapy for Head-and-Neck Cancer: A Retrospective Study. International journal of radiation oncology, biology, physics	CW Chang, D Bohannon, Z Tian, Y Wang, MW McDonald, DS Yu, T Liu, J Zhou, X Yang	10/01/2023
DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining. Nucleic acids research	PE Head, P Kapoor-Vazirani, GP Nagaraju, H Zhang, SK Rath, NC Luong, R Haji-Seyed-Javadi, F Sesay, SY Wang, DM Duong, W Daddacha, EV Minten, B Song, D Danelia, X Liu, S Li, EA Ortlund, NT Seyfried, DM Smalley, Y Wang, X Deng, WS Dynan, B El-Rayes, AJ Davis, DS Yu	08/25/2023
Author Correction: YB1 modulates the DNA damage response in medulloblastoma. Scientific reports	LF McSwain, CE Pillsbury, R Haji-Seyed-Javadi, SK Rath, V Chen, T Huang, SW Shahab, H Kunhiraman, J Ross, GA Price, A Dey, D Hambardzumyan, T MacDonald, DS Yu, CC Porter, AM Kenney	06/15/2023
YB1 modulates the DNA damage response in medulloblastoma. Scientific reports	LF McSwain, CE Pillsbury, R Haji-Seyed-Javadi, SK Rath, V Chen, T Huang, SW Shahab, H Kunhiraman, J Ross, GA Price, A Dey, D Hambardzumyan, T MacDonald, DS Yu, CC Porter, AM Kenney	05/19/2023
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops. bioRxiv : the preprint server for biology	JL de Amorim, SW Leung, R Haji-Seyed-Javadi, Y Hou, DS Yu, H Ghalei, S Khoshnevis, B Yao, AH Corbett	04/17/2023
Deformable CT image registration via a dual feasible neural network. Medical physics	Y Lei, Y Fu, Z Tian, T Wang, X Dai, J Roper, DS Yu, M McDonald, JD Bradley, T Liu, J Zhou, X Yang	12/01/2022
SAMHD1 deacetylation by SIRT1 promotes DNA end resection by facilitating DNA binding at double-strand breaks. Nature communications	P Kapoor-Vazirani, SK Rath, X Liu, Z Shu, NE Bowen, Y Chen, R Haji-Seyed-Javadi, W Daddacha, EV Minten, D Danelia, D Farchi, DM Duong, NT Seyfried, X Deng, EA Ortlund, B Kim, DS Yu	11/07/2022
Protocol for in vitro lysine deacetylation to test putative substrates of class III deacetylases. STAR protocols	EV Minten, DS Yu	06/17/2022
Bempegaldesleukin plus nivolumab in first-line renal cell carcinoma: results from the PIVOT-02 study. Journal for immunotherapy of cancer	NM Tannir, DC Cho, A Diab, M Sznol, MA Bilen, AV Balar, G Grignani, E Puente, L Tang, D Chien, U Hoch, A Choudhury, D Yu, SL Currie, MA Tagliaferri, J Zalevsky, AO Siefker-Radtke, ME Hurwitz	04/01/2022
Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates. Scientific reports	H Zhang, EB Dammer, DM Duong, D Danelia, NT Seyfried, DS Yu	03/09/2022
Structural and functional characterization explains loss of dNTPase activity of the cancer-specific R366C/H mutant SAMHD1 proteins. The Journal of biological chemistry	NE Bowen, J Temple, C Shepard, A Oo, F Arizaga, P Kapoor-Vazirani, M Persaud, CH Yu, DH Kim, RF Schinazi, DN Ivanov, F Diaz-Griffero, DS Yu, Y Xiong, B Kim	10/01/2021
SIRT2 promotes BRCA1-BARD1 heterodimerization through deacetylation. Cell reports	EV Minten, P Kapoor-Vazirani, C Li, H Zhang, K Balakrishnan, DS Yu	03/30/2021
EZH2 has a non-catalytic and PRC2-independent role in stabilizing DDB2 to promote nucleotide excision repair. Oncogene	AE Koyen, MZ Madden, D Park, EV Minten, P Kapoor-Vazirani, E Werner, NT Pfister, R Haji-Seyed-Javadi, H Zhang, J Xu, N Deng, DM Duong, TJ Pecen, Z Frazier, ZD Nagel, JB Lazaro, KW Mouw, NT Seyfried, CS Moreno, TK Owonikoko, X Deng, DS Yu	06/01/2020
Withdrawal: Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. The Journal of biological chemistry	H Wang, X Wang, G Chen, X Zhang, X Tang, D Park, FA Cucinotta, DS Yu, X Deng, WS Dynan, PW Doetsch, Y Wang	05/01/2020
Replication stress and FOXM1 drive radiation induced genomic instability and cell transformation. PloS one	Z Li, DS Yu, PW Doetsch, E Werner	01/01/2020
Ionizing Radiation induction of cholesterol biosynthesis in Lung tissue. Scientific reports	E Werner, A Alter, Q Deng, EB Dammer, Y Wang, DS Yu, DM Duong, NT Seyfried, PW Doetsch	08/29/2019
Survival outcomes by high-risk human papillomavirus status in nonoropharyngeal head and neck squamous cell carcinomas: A propensity-scored analysis of the National Cancer Data Base. Cancer	S Tian, JM Switchenko, J Jhaveri, RJ Cassidy, MJ Ferris, RH Press, NT Pfister, MR Patel, NF Saba, MW McDonald, KA Higgins, DS Yu, WJ Curran, TW Gillespie, JJ Beitler	08/15/2019
Acetylation regulates ribonucleotide reductase activity and cancer cell growth. Nature communications	G Chen, Y Luo, K Warncke, Y Sun, DS Yu, H Fu, M Behera, SS Ramalingam, PW Doetsch, DM Duong, M Lammers, WJ Curran, X Deng	07/19/2019
Disparities in Postoperative Therapy for Salivary Gland Adenoid Cystic Carcinomas. The Laryngoscope	RJ Cassidy, JM Switchenko, MW El-Deiry, RH Belcher, J Zhong, CE Steuer, NF Saba, MW McDonald, DS Yu, TW Gillespie, JJ Beitler	02/01/2019
Targeting Mcl-1 enhances DNA replication stress sensitivity to cancer therapy. The Journal of clinical investigation	G Chen, AT Magis, K Xu, D Park, DS Yu, TK Owonikoko, GL Sica, SW Satola, SS Ramalingam, WJ Curran, PW Doetsch, X Deng	01/02/2018
CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy. International journal of breast cancer	AJ Schlafstein, AE Withers, S Rudra, D Danelia, JM Switchenko, D Mister, S Harari, H Zhang, W Daddacha, S Ehdaivand, X Li, MA Torres, DS Yu	01/01/2018
SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination. Cell reports	W Daddacha, AE Koyen, AJ Bastien, PE Head, VR Dhere, GN Nabeta, EC Connolly, E Werner, MZ Madden, MB Daly, EV Minten, DR Whelan, AJ Schlafstein, H Zhang, R Anand, C Doronio, AE Withers, C Shepard, RK Sundaram, X Deng, WS Dynan, Y Wang, RS Bindra, P Cejka, E Rothenberg, PW Doetsch, B Kim, DS Yu	08/22/2017
Sirtuin 2 mutations in human cancers impair its function in genome maintenance. The Journal of biological chemistry	PE Head, H Zhang, AJ Bastien, AE Koyen, AE Withers, WB Daddacha, X Cheng, DS Yu	06/16/2017
SIRT2 orchestrates the DNA damage response. Cell cycle (Georgetown, Tex.)	H Zhang, PE Head, DS Yu	08/17/2016
TNFRSF10C copy number variation is associated with metastatic colorectal cancer. Journal of gastrointestinal oncology	DG Tanenbaum, WA Hall, LE Colbert, AJ Bastien, DJ Brat, J Kong, S Kim, B Dwivedi, J Kowalski, JC Landry, DS Yu	06/01/2016
Chromodomain-helicase-DNA binding protein 5, 7 and pronecrotic mixed lineage kinase domain-like protein serve as potential prognostic biomarkers in patients with resected pancreatic adenocarcinomas. World journal of gastrointestinal oncology	CS Seldon, LE Colbert, WA Hall, SB Fisher, DS Yu, JC Landry	04/15/2016
ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA. Cell reports	H Zhang, PE Head, W Daddacha, SH Park, X Li, Y Pan, MZ Madden, DM Duong, M Xie, B Yu, MD Warren, EA Liu, VR Dhere, C Li, I Pradilla, MA Torres, Y Wang, WS Dynan, PW Doetsch, X Deng, NT Seyfried, D Gius, DS Yu	02/16/2016
Cholangiocarcinoma size on magnetic resonance imaging versus pathologic specimen: Implications for radiation treatment planning. Practical radiation oncology	DG Tanenbaum, WA Hall, P Mittal, DC Nickleach, JL Mikell, LE Colbert, CC Moreno, MH Squires, SB Fisher, DS Yu, DA Kooby, SK Maithel, JC Landry	01/01/2016
Quantitative Ultrasonic Nakagami Imaging of Neck Fibrosis After Head and Neck Radiation Therapy. International journal of radiation oncology, biology, physics	X Yang, E Yoshida, RJ Cassidy, JJ Beitler, DS Yu, WJ Curran, T Liu	06/01/2015
Radiotherapy patterns of care in gastric adenocarcinoma: a single institution experience. Journal of gastrointestinal oncology	J Cheng, MH Squires, JL Mikell, SB Fisher, CA Staley, DA Kooby, BF El-Rayes, WJ Curran, WA Hall, LE Colbert, JW Shelton, SK Maithel, J Landry, DS Yu	06/01/2015
The 21-gene recurrence score and locoregional recurrence in breast cancer patients. Annals of surgical oncology	NK Jegadeesh, S Kim, RS Prabhu, GM Oprea, DS Yu, KG Godette, AB Zelnak, D Mister, JM Switchenko, MA Torres	04/01/2015
Locoregional and Distant Recurrence Patterns in Young versus Elderly Women Treated for Breast Cancer. International journal of breast cancer	S Rudra, DS Yu, ES Yu, JM Switchenko, D Mister, MA Torres	01/01/2015
Locoregional Recurrence Risk in Breast Cancer Patients with Estrogen Receptor Positive Tumors and Residual Nodal Disease following Neoadjuvant Chemotherapy and Mastectomy without Radiation Therapy. International journal of breast cancer	S Kandula, JM Switchenko, S Harari, C Fasola, D Mister, DS Yu, AB Zelnak, MA Torres	01/01/2015
Automated segmentation of the parotid gland based on atlas registration and machine learning: a longitudinal MRI study in head-and-neck radiation therapy. International journal of radiation oncology, biology, physics	X Yang, N Wu, G Cheng, Z Zhou, DS Yu, JJ Beitler, WJ Curran, T Liu	12/01/2014
Low CHD5 expression activates the DNA damage response and predicts poor outcome in patients undergoing adjuvant therapy for resected pancreatic cancer. Oncogene	WA Hall, AV Petrova, LE Colbert, CW Hardy, SB Fisher, B Saka, JW Shelton, MD Warren, BG Pantazides, K Gandhi, J Kowalski, DA Kooby, BF El-Rayes, CA Staley, N Volkan Adsay, WJ Curran, JC Landry, SK Maithel, DS Yu	11/20/2014
Diagnostic accuracy of ultrasonic histogram features to evaluate radiation toxicity of the parotid glands: a clinical study of xerostomia following head-and-neck cancer radiotherapy. Academic radiology	X Yang, S Tridandapani, JJ Beitler, DS Yu, Z Chen, S Kim, DW Bruner, WJ Curran, T Liu	10/01/2014
A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress response. Nucleic acids research	SC Smith, AV Petrova, MZ Madden, H Wang, Y Pan, MD Warren, CW Hardy, D Liang, EA Liu, MH Robinson, S Rudra, J Wang, S Ehdaivand, MA Torres, Y Wang, DS Yu	10/01/2014
Indocyanine green loaded liposome nanocarriers for photodynamic therapy using human triple negative breast cancer cells. Photodiagnosis and photodynamic therapy	CS Shemesh, CW Hardy, DS Yu, B Fernandez, H Zhang	06/01/2014
CHD7 expression predicts survival outcomes in patients with resected pancreatic cancer. Cancer research	LE Colbert, AV Petrova, SB Fisher, BG Pantazides, MZ Madden, CW Hardy, MD Warren, Y Pan, GP Nagaraju, EA Liu, B Saka, WA Hall, JW Shelton, K Gandhi, R Pauly, J Kowalski, DA Kooby, BF El-Rayes, CA Staley, NV Adsay, WJ Curran, JC Landry, SK Maithel, DS Yu	05/15/2014
Ultrasonic Nakagami-parameter characterization of parotid-gland injury following head-and-neck radiotherapy: a feasibility study of late toxicity. Medical physics	X Yang, S Tridandapani, JJ Beitler, DS Yu, N Wu, Y Wang, DW Bruner, WJ Curran, T Liu	02/01/2014
Pronecrotic mixed lineage kinase domain-like protein expression is a prognostic biomarker in patients with early-stage resected pancreatic adenocarcinoma. Cancer	LE Colbert, SB Fisher, CW Hardy, WA Hall, B Saka, JW Shelton, AV Petrova, MD Warren, BG Pantazides, K Gandhi, J Kowalski, DA Kooby, BF El-Rayes, CA Staley, NV Adsay, WJ Curran, JC Landry, SK Maithel, DS Yu	09/01/2013
SIRT2 directs the replication stress response through CDK9 deacetylation. Proceedings of the National Academy of Sciences of the United States of America	H Zhang, SH Park, BG Pantazides, O Karpiuk, MD Warren, CW Hardy, DM Duong, SJ Park, HS Kim, A Vassilopoulos, NT Seyfried, SA Johnsen, D Gius, DS Yu	08/13/2013
Segmentation editing improves efficiency while reducing inter-expert variation and maintaining accuracy for normal brain tissues in the presence of space-occupying lesions. Physics in medicine and biology	MA Deeley, A Chen, RD Datteri, J Noble, A Cmelak, E Donnelly, A Malcolm, L Moretti, J Jaboin, K Niermann, ES Yang, DS Yu, BM Dawant	06/21/2013
Ultrasound GLCM texture analysis of radiation-induced parotid-gland injury in head-and-neck cancer radiotherapy: an in vivo study of late toxicity. Medical physics	X Yang, S Tridandapani, JJ Beitler, DS Yu, EJ Yoshida, WJ Curran, T Liu	09/01/2012
Ultrasound histogram assessment of parotid gland injury following head-and-neck radiotherapy: a feasibility study. Ultrasound in medicine & biology	X Yang, S Tridandapani, JJ Beitler, DS Yu, EJ Yoshida, WJ Curran, T Liu	09/01/2012
One stone, two birds: CDK9-directed activation of UBE2A regulates monoubiquitination of both H2B and PCNA. Cell cycle (Georgetown, Tex.)	H Zhang, DS Yu	07/01/2012
The negative effect of triple-negative breast cancer on outcome after breast-conserving therapy. Annals of surgical oncology	SS Zaky, M Lund, KA May, KD Godette, JJ Beitler, LR Holmes, RM O'Regan, ES Yu, DS Yu, JC Landry	10/01/2011
Comparison of manual and automatic segmentation methods for brain structures in the presence of space-occupying lesions: a multi-expert study. Physics in medicine and biology	MA Deeley, A Chen, R Datteri, JH Noble, AJ Cmelak, EF Donnelly, AW Malcolm, L Moretti, J Jaboin, K Niermann, ES Yang, DS Yu, F Yei, T Koyama, GX Ding, BM Dawant	07/21/2011
A role for CDK9-cyclin K in maintaining genome integrity. Cell cycle (Georgetown, Tex.)	DS Yu, D Cortez	01/01/2011
Cyclin-dependent kinase 9-cyclin K functions in the replication stress response. EMBO reports	DS Yu, R Zhao, EL Hsu, J Cayer, F Ye, Y Guo, Y Shyr, D Cortez	11/01/2010

Awards

Dr. Yu received the Michael Fry Research Award from the Radiation Research Society in 2014, which recognizes the most outstanding junior scientist who has made exceptional contributions to the field of radiation research. Dr. Yu is currently funded by NIH/NCI R01, Department of Defense, and foundation awards.