Arash Grakoui, PhD

Research Program

Cancer Immunology
Phone Number

404-727-7822
Email Address

arash.grakoui@emory.edu

Biography

Arash Grakoui, PhD, is a professor in the Division of Infectious Diseases in the Department of Medicine and a professor in the Department of Microbiology and Immunology at Emory University School of Medicine. Additionally, Dr. Grakoui is a core scientist and the director of graduate studies program in Immunology and Molecular Pathogenesis at Emory National Primate Research Center. He is also an investigator at Emory Center for AIDS research.

Dr. Grakoui is a member of the Cancer Immunology Research Program at Winship Cancer Institute.

Education

Dr. Grakoui received his PhD in Immunology from Washington University in St. Louis. He then went on to perform his post-doctoral fellowship as a Cancer Research Institute Fellow in viral immunology at The Rockefeller University in New York.

Titles & Roles

Professor, Department of Medicine, Division of Infectious

Emory University School of Medicine
Professor, Department of Microbiology and Immunology

Emory University School of Medicine
Director of Graduate Studies, Immunology and Molecular Pathogenesis Program

Emory National Primate Research Center

Research

Dr. Grakoui's research is focused on understanding the inextricable connectivity between chronic viral infections and the immune system. His research is committed to making significant contributions to the understanding of liver disease and to the development and application of immunotherapy aimed at controlling chronic viral replication and end-stage liver disease ultimately preventing detrimental hepatic consequences.

Grants

View Grants

Grant Number	Title
1U19AI159819-01	Correlates of protective immunity to HCV and rational vaccine design
1U19AI159819-01	Correlates of protective immunity to HCV and rational vaccine design: Admin Core
1U19AI159819-01	Correlates of protective immunity to HCV and rational vaccine design: Project 2
5U19AI159819-02	Correlates of protective immunity to HCV and rational vaccine design
5U19AI159819-02	Correlates of protective immunity to HCV and rational vaccine design: Admin Core
5U19AI159819-02	Correlates of protective immunity to HCV and rational vaccine design: Project 2
5U19AI159819-03	Correlates of protective immunity to HCV and rational vaccine design
5U19AI159819-03	Correlates of protective immunity to HCV and rational vaccine design: Admin Core
5U19AI159819-03	Correlates of protective immunity to HCV and rational vaccine design: Project 2
5U19AI159819-04	Correlates of protective immunity to HCV and rational vaccine design

Publications

Title/Journal	Authors	Publication Date
Hyperfunctional T cell responses unchecked by regulatory T cells are unable to resolve hepaciviral infection without humoral contribution. Journal of hepatology	F Jin, J Gridley, A Kumari, A Saeidi, B Holland, E Elrod, P Dravid, S Trivedi, A Kapoor, M Thapa, A Grakoui	04/01/2025
Activation-Induced Marker Assay to Identify and Isolate HCV-Specific T Cells for Single-Cell RNA-Seq Analysis. Viruses	M Eisa, N Flores, O Khedr, E Gomez-Escobar, N Bédard, NF Abdeltawab, J Bruneau, A Grakoui, NH Shoukry	10/17/2024
Concerted synergy between viral-specific IgG and CD8 + T cells is critical for clearance of an HCV-related rodent hepacivirus. Hepatology (Baltimore, Md.)	J Gridley, B Holland, E Salinas, S Trivedi, P Dravid, E Elrod, F Jin, A Kumari, MN Batista, M Thapa, CM Rice, J Marcotrigiano, A Kapoor, A Grakoui	10/01/2024
CD4⁺ and CD8⁺ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment. Science advances	M Kar, KEE Johnson, A Vanderheiden, EJ Elrod, K Floyd, E Geerling, ET Stone, E Salinas, S Banakis, W Wang, S Sathish, S Shrihari, ME Davis-Gardner, J Kohlmeier, A Pinto, R Klein, A Grakoui, E Ghedin, MS Suthar	08/23/2024
Eosinophils protect against SARS-CoV-2 following a vaccine breakthrough infection. bioRxiv : the preprint server for biology	KM Moore, SL Foster, M Kar, KA Floyd, EJ Elrod, ME Williams, JV Velden, M Ellis, A Malik, B Wali, S Lapp, A Metz, SE Bosinger, VD Menachery, RA Seder, RR Amara, JE Kohlmeier, A Grakoui, MS Suthar	08/10/2024
BiliQML: a supervised machine-learning model to quantify biliary forms from digitized whole slide liver histopathological images. American journal of physiology. Gastrointestinal and liver physiology	DJ Hellen, ME Fay, DH Lee, C Klindt-Morgan, A Bennett, KJ Pachura, A Grakoui, SS Huppert, PA Dawson, WA Lam, SJ Karpen	07/01/2024
CD4+ and CD8+ T cells are required to prevent SARS-CoV-2 persistence in the nasal compartment. bioRxiv : the preprint server for biology	M Kar, KEE Johnson, A Vanderheiden, EJ Elrod, K Floyd, E Geerling, ET Stone, E Salinas, S Banakis, W Wang, S Sathish, S Shrihari, ME Davis-Gardner, J Kohlmeier, A Pinto, R Klein, A Grakoui, E Ghedin, MS Suthar	01/24/2024
Coordinated expansion of memory T follicular helper and B cells mediates spontaneous clearance of HCV reinfection. Frontiers in immunology	M Eisa, E Gomez-Escobar, N Bédard, NF Abdeltawab, N Flores, S Mazouz, A Fieffé-Bédard, P Sakayan, J Gridley, MS Abdel-Hakeem, J Bruneau, A Grakoui, NH Shoukry	01/01/2024
Soluble ORF2 protein enhances HEV replication and induces long-lasting antibody response and protective immunity in vivo. Hepatology (Baltimore, Md.)	P Ralfs, B Holland, E Salinas, B Bremer, M Wang, J Zhu, C Ambardekar, H Blasczyk, CM Walker, Z Feng, A Grakoui	12/01/2023
Phenotype and fate of liver-resident CD8 T cells during acute and chronic hepacivirus infection. PLoS pathogens	P Dravid, S Murthy, Z Attia, C Cassady, R Chandra, S Trivedi, A Vyas, J Gridley, B Holland, A Kumari, A Grakoui, JM Cullen, CM Walker, H Sharma, A Kapoor	10/01/2023
Translocation of gut commensal bacteria to the brain. bioRxiv : the preprint server for biology	M Thapa, A Kumari, CY Chin, JE Choby, F Jin, B Bogati, DM Chopyk, N Koduri, A Pahnke, EJ Elrod, EM Burd, DS Weiss, A Grakoui	09/01/2023
Western diet dampens T regulatory cell function to fuel hepatic inflammation in nonalcoholic fatty liver disease. bioRxiv : the preprint server for biology	S Chaudhary, R Rai, PB Pal, D Tedesco, AD Singhi, SP Monga, A Grakoui, SS Iyer, R Raeman	03/25/2023
Regions of hepatitis C virus E2 required for membrane association. Nature communications	A Kumar, TC Rohe, EJ Elrod, AG Khan, AD Dearborn, R Kissinger, A Grakoui, J Marcotrigiano	01/26/2023
Neutralization and receptor use of infectious culture-derived rat hepacivirus as a model for HCV. Hepatology (Baltimore, Md.)	R Wolfisberg, CE Thorselius, E Salinas, E Elrod, S Trivedi, L Nielsen, U Fahnøe, A Kapoor, A Grakoui, CM Rice, J Bukh, K Holmbeck, TKH Scheel	11/01/2022
Differential immune transcriptomic profiles between vaccinated and resolved HCV reinfected subjects. PLoS pathogens	S Mazouz, E Salinas, N Bédard, A Filali, O Khedr, L Swadling, MS Abdel-Hakeem, A Siddique, E Barnes, J Bruneau, A Grakoui, NH Shoukry	11/01/2022
Serum neutralization activity declines but memory B cells persist after cure of chronic hepatitis C. Nature communications	A Nishio, S Hasan, H Park, N Park, JH Salas, E Salinas, L Kardava, P Juneau, N Frumento, G Massaccesi, S Moir, JR Bailey, A Grakoui, MG Ghany, B Rehermann	09/16/2022
Erratum for Vanderheiden et al., "CCR2 Signaling Restricts SARS-CoV-2 Infection". mBio	A Vanderheiden, J Thomas, AL Soung, ME Davis-Gardner, K Floyd, F Jin, DA Cowan, K Pellegrini, A Creanga, A Pegu, A Derrien-Colemyn, PY Shi, A Grakoui, RS Klein, SE Bosinger, JE Kohlmeier, VD Menachery, MS Suthar	06/28/2022
mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 omicron variant. Cell reports. Medicine	VV Edara, KE Manning, M Ellis, L Lai, KM Moore, SL Foster, K Floyd, ME Davis-Gardner, G Mantus, LE Nyhoff, S Bechnak, G Alaaeddine, A Naji, H Samaha, M Lee, L Bristow, M Gagne, J Roberts-Torres, AR Henry, S Godbole, A Grakoui, M Saxton, A Piantadosi, JJ Waggoner, DC Douek, N Rouphael, J Wrammert, MS Suthar	02/15/2022
mRNA-1273 and BNT162b2 mRNA vaccines have reduced neutralizing activity against the SARS-CoV-2 Omicron variant. bioRxiv : the preprint server for biology	VV Edara, KE Manning, M Ellis, L Lai, KM Moore, SL Foster, K Floyd, ME Davis-Gardner, G Mantus, LE Nyhoff, S Bechnak, G Alaaeddine, A Naji, H Samaha, M Lee, L Bristow, L Hussaini, CR Ciric, PV Nguyen, M Gagne, J Roberts-Torres, AR Henry, S Godbole, A Grakoui, M Sexton, A Piantadosi, JJ Waggoner, DC Douek, EJ Anderson, N Rouphael, J Wrammert, MS Suthar	12/22/2021
CCR2 Signaling Restricts SARS-CoV-2 Infection. mBio	A Vanderheiden, J Thomas, AL Soung, ME Davis-Gardner, K Floyd, F Jin, DA Cowan, K Pellegrini, PY Shi, A Grakoui, RS Klein, SE Bosinger, JE Kohlmeier, VD Menachery, MS Suthar	12/21/2021
Structural insights into hepatitis C virus receptor binding and entry. Nature	A Kumar, RA Hossain, SA Yost, W Bu, Y Wang, AD Dearborn, A Grakoui, JI Cohen, J Marcotrigiano	10/01/2021
Resolution of hepatitis E virus infection in CD8+ T cell-depleted rhesus macaques. Journal of hepatology	W Bremer, H Blasczyk, X Yin, E Salinas, A Grakoui, Z Feng, C Walker	09/01/2021
Plasmacytoid dendritic cells produce type I interferon and reduce viral replication in airway epithelial cells after SARS-CoV-2 infection. bioRxiv : the preprint server for biology	L Cervantes-Barragan, A Vanderheiden, CJ Royer, ME Davis-Gardner, P Ralfs, T Chirkova, LJ Anderson, A Grakoui, MS Suthar	05/13/2021
CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection. bioRxiv : the preprint server for biology	A Vanderheiden, J Thomas, AL Soung, ME Davis-Gardner, K Floyd, F Jin, DA Cowan, K Pellegrini, A Creanga, A Pegu, A Derrien-Colemyn, PY Shi, A Grakoui, RS Klein, SE Bosinger, JE Kohlmeier, VD Menachery, MS Suthar	05/04/2021
Immune system control of hepatitis C virus infection. Current opinion in virology	JD Stuart, E Salinas, A Grakoui	02/01/2021
Early T follicular helper cell activity accelerates hepatitis C virus-specific B cell expansion. The Journal of clinical investigation	E Salinas, M Boisvert, AA Upadhyay, N Bédard, SA Nelson, J Bruneau, CA Derdeyn, J Marcotrigiano, MJ Evans, SE Bosinger, NH Shoukry, A Grakoui	01/19/2021
Type I and Type III Interferons Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures. Journal of virology	A Vanderheiden, P Ralfs, T Chirkova, AA Upadhyay, MG Zimmerman, S Bedoya, H Aoued, GM Tharp, KL Pellegrini, C Manfredi, E Sorscher, B Mainou, JL Lobby, JE Kohlmeier, AC Lowen, PY Shi, VD Menachery, LJ Anderson, A Grakoui, SE Bosinger, MS Suthar	09/15/2020
Contribution of the Intestinal Microbiome and Gut Barrier to Hepatic Disorders. Gastroenterology	DM Chopyk, A Grakoui	09/01/2020
Blockade of BAFF Reshapes the Hepatic B Cell Receptor Repertoire and Attenuates Autoantibody Production in Cholestatic Liver Disease. Journal of immunology (Baltimore, Md. : 1950)	M Thapa, D Tedesco, S Gumber, EJ Elrod, JH Han, WH Kitchens, JF Magliocca, AB Adams, A Grakoui	06/15/2020
Monkey in the Middle: Dynamics of Interspecies Antibody Responses. Gastroenterology	E Salinas, A Grakoui	03/01/2020
Mechanotransduction in T Cell Development, Differentiation and Function. Cells	M Rushdi, K Li, Z Yuan, S Travaglino, A Grakoui, C Zhu	02/05/2020
CD4+ T cell restoration and control of hepatitis C virus replication after childbirth. The Journal of clinical investigation	SL Coss, A Torres-Cornejo, MR Prasad, M Moore-Clingenpeel, A Grakoui, GM Lauer, CM Walker, JR Honegger	02/03/2020
Acetaminophen Intoxication Rapidly Induces Apoptosis of Intestinal Crypt Stem Cells and Enhances Intestinal Permeability. Hepatology communications	DM Chopyk, JD Stuart, MG Zimmerman, J Wen, S Gumber, MS Suthar, M Thapa, MJ Czaja, A Grakoui	11/01/2019
EphB2 receptor tyrosine kinase promotes hepatic fibrogenesis in mice via activation of hepatic stellate cells. Scientific reports	PN Mimche, CM Lee, SM Mimche, M Thapa, A Grakoui, M Henkemeyer, TJ Lamb	02/07/2018

Awards

Dr. Grakoui has received numerous awards and honors including:

Data and Safety Monitoring Board (DSMB) Member, Nationwide Children's Hospital, Ohio State University, 2018-Present
Data and Safety Monitoring Board Member, IDEXX Laboratories, 2018-Present
Member, Immunity and Host Defense (IHD) Study Section, NIH, 2013-2019
Editorial Board, Hepatology, 2011-2019
Editorial Board, Clinical and Experimental Medicine, 2012-2016
AASLD/American Liver Foundation; Member Review Committee, 2011-2015
MilliPub Club Award, faculty members who have published papers that has been cited over 1000 times by their peers, as compiled by Web of Science, 2011
Cancer Research Institute Investigator, 2005-2010
Early career faculty research award, Emory University, 2007
Cancer Research Institute Postdoctoral Fellow, 2001-2004