Chunhui Xu, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-7774
Email Address

chunhui.xu@emory.edu

Biography

Chunhui Xu, PhD, is a professor in the Department of Pediatrics at Emory University School of Medicine.

Dr. Xu is member of the Cell and Molecular Biology Research Program at Winship Cancer Institute.

Education

Dr. Xu received her PhD from the University of Georgia in Athens, Georgia. She completed her postdoctoral training at the Burnham Institute in San Diego, California.

Titles & Roles

Professor, Department of Pediatrics

Emory University School of Medicine

Research

Research in Dr. Xu's laboratory is focused on human cardiomyocytes derived from human pluripotent stem cells, which hold promise for cardiac cell therapy, disease modeling, drug discovery and the study of developmental biology. They are also collaborating with investigators at Georgia Tech, Emory University, and Children's Healthcare of Atlanta, to explore the application of nanotechnology and tissue engineering in stem cell research.

Publications

Title/Journal	Authors	Publication Date
Spaceflight alters protein levels and gene expression associated with stress response and metabolic characteristics in human cardiac spheroids. Biomaterials	P Forghani, W Liu, Z Wang, Z Ling, F Takaesu, E Yang, GK Tharp, S Nielsen, S Doraisingam, S Countryman, ME Davis, R Wu, S Jia, C Xu	06/01/2025
Multiscale and recursive unmixing of spatiotemporal rhythms for live-cell and intravital cardiac microscopy. Nature cardiovascular research	Z Ling, W Liu, K Yoon, J Hou, P Forghani, X Hua, H Yoon, M Bagheri, LP Dasi, B Mandracchia, C Xu, S Nie, S Jia	05/07/2025
Ethanol exposure during differentiation of human induced pluripotent stem cells reduces cardiomyocyte generation and alters metabolism. Life sciences	K Man, L Fu, A Lane, F Harris, O Reid, LC Armand, P Forghani, R Wu, V Faundez, LA Brown, C Xu	03/01/2025
High-speed optical imaging with sCMOS pixel reassignment. Nature communications	B Mandracchia, C Zheng, S Rajendran, W Liu, P Forghani, C Xu, S Jia	05/30/2024
Simulated microgravity improves maturation of cardiomyocytes derived from human induced pluripotent stem cells. Scientific reports	P Forghani, A Rashid, LC Armand, D Wolfson, R Liu, HC Cho, JT Maxwell, H Jo, K Salaita, C Xu	01/26/2024
Space microgravity increases expression of genes associated with proliferation and differentiation in human cardiac spheres. NPJ microgravity	H Hwang, A Rampoldi, P Forghani, D Li, J Fite, G Boland, K Maher, C Xu	12/09/2023
AMPK activator-treated human cardiac spheres enhance maturation and enable pathological modeling. Stem cell research & therapy	D Li, LC Armand, F Sun, H Hwang, D Wolfson, A Rampoldi, R Liu, P Forghani, X Hu, WM Yu, CK Qu, DP Jones, R Wu, HC Cho, JT Maxwell, C Xu	11/08/2023
Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice. eLife	H Zheng, Q Li, S Li, Z Li, M Brotto, D Weiss, D Prosdocimo, C Xu, A Reddy, M Puchowicz, X Zhao, MN Weitzmann, MK Jain, CK Qu	09/06/2023
Optimal sparsity allows reliable system-aware restoration of fluorescence microscopy images. Science advances	B Mandracchia, W Liu, X Hua, P Forghani, S Lee, J Hou, S Nie, C Xu, S Jia	09/01/2023
Chronic ethanol exposure induces mitochondrial dysfunction and alters gene expression and metabolism in human cardiac spheroids. Alcohol, clinical & experimental research	H Hwang, R Liu, R Eldridge, X Hu, P Forghani, DP Jones, C Xu	04/01/2023
Downstream bioprocessing of human pluripotent stem cell-derived therapeutics. Engineering in life sciences	S Sart, C Liu, EZ Zeng, C Xu, Y Li	11/01/2022
Space microgravity improves proliferation of human iPSC-derived cardiomyocytes. Stem cell reports	A Rampoldi, P Forghani, D Li, H Hwang, LC Armand, J Fite, G Boland, J Maxwell, K Maher, C Xu	10/11/2022
A 3D Bioprinted in vitro Model of Neuroblastoma Recapitulates Dynamic Tumor-Endothelial Cell Interactions Contributing to Solid Tumor Aggressive Behavior. Advanced science (Weinheim, Baden-Wurttemberg, Germany)	L Ning, J Shim, ML Tomov, R Liu, R Mehta, A Mingee, B Hwang, L Jin, A Mantalaris, C Xu, M Mahmoudi, KC Goldsmith, V Serpooshan	08/01/2022
Carfilzomib Treatment Causes Molecular and Functional Alterations of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Journal of the American Heart Association	P Forghani, A Rashid, F Sun, R Liu, D Li, MR Lee, H Hwang, JT Maxwell, A Mandawat, R Wu, K Salaita, C Xu	12/21/2021
Chronic Ethanol Exposure Induces Deleterious Changes in Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells. Stem cell reviews and reports	R Liu, F Sun, LC Armand, R Wu, C Xu	12/01/2021
Functional and molecular effects of TNF-α on human iPSC-derived cardiomyocytes. Stem cell research	A Saraf, A Rampoldi, M Chao, D Li, L Armand, H Hwang, R Liu, R Jha, H Fu, JT Maxwell, C Xu	04/01/2021
Cryopreservation and CO₂-independent culture of 3D cardiac progenitors for spaceflight experiments. Biomaterials	A Rampoldi, R Jha, J Fite, G Boland, C Xu	02/01/2021
Melphalan induces cardiotoxicity through oxidative stress in cardiomyocytes derived from human induced pluripotent stem cells. Stem cell research & therapy	R Liu, D Li, F Sun, A Rampoldi, JT Maxwell, R Wu, P Fischbach, SM Castellino, Y Du, H Fu, A Mandawat, C Xu	11/05/2020
Proteomic Profiling Reveals Roles of Stress Response, Ca²⁺ Transient Dysregulation, and Novel Signaling Pathways in Alcohol-Induced Cardiotoxicity. Alcoholism, clinical and experimental research	R Liu, F Sun, P Forghani, LC Armand, A Rampoldi, D Li, R Wu, C Xu	11/01/2020
A long non-coding RNA GATA6-AS1 adjacent to GATA6 is required for cardiomyocyte differentiation from human pluripotent stem cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology	R Jha, D Li, Q Wu, KE Ferguson, P Forghani, GC Gibson, C Xu	11/01/2020
Machine learning identifies abnormal Ca²⁺ transients in human induced pluripotent stem cell-derived cardiomyocytes. Scientific reports	H Hwang, R Liu, JT Maxwell, J Yang, C Xu	10/12/2020
Human iPSC-derived mesenchymal stem cells encapsulated in PEGDA hydrogels mature into valve interstitial-like cells. Acta biomaterialia	ALY Nachlas, S Li, R Jha, M Singh, C Xu, ME Davis	04/15/2018