Bing Yao, PhD

Research Program

Cell and Molecular Biology
Phone Number

404-727-3757
Email Address

bing.yao@emory.edu

Biography

Bing Yao, PhD is an associate professor in the Department of Human Genetics at Emory University School of Medicine. Dr. Yao is a member of the Cell and Molecular Biology Research Program at Winship Cancer Institute of Emory University.

Education

Dr. Yao received his PhD from University of Florida in Gainesville, Florida. He completed his postdoctoral training at Emory University in Atlanta, Georgia.

Titles & Roles

Associate Professor, Department of Human Genetics

Emory University School of Medicine

Research

Dr. Yao's long-term research interests are to understand the pivotal roles of epigenetic regulation, especially various forms of covalent DNA and RNA modifications, in normal brain functions, as well as how dysregulation of these processes may contribute to human brain disorders. By using the mouse as a primary model system, his lab combines genetics, molecular biology, biochemistry, cell biology and bioinformatics systems to continuously push the boundaries of their understanding regarding the molecular mechanisms of these epigenetic markers in the central nervous system.

Publications

Title/Journal	Authors	Publication Date
Brain 5-hydroxymethylcytosine alterations are associated with Alzheimer's disease neuropathology. Nature communications	J Zhao, T Gu, C Gao, G Miao, H Palma-Gudiel, L Yu, J Yang, Y Wang, Y Li, J Lim, R Li, B Yao, H Wu, JA Schneider, N Seyfried, F Grodstein, PL De Jager, P Jin, DA Bennett	03/22/2025
Mapping the developmental trajectory of human astrocytes reveals divergence in glioblastoma. Nature cell biology	C Sojka, HV Wang, TN Bhatia, Y Li, P Chopra, A Sing, A Voss, A King, F Wang, K Joseph, VM Ravi, J Olson, K Hoang, E Nduom, VG Corces, B Yao, SA Sloan	02/01/2025
Basic Science and Pathogenesis. Alzheimer's & dementia : the journal of the Alzheimer's Association	F Wang, Y Li, H Shen, Y Feng, B Yao	12/01/2024
Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease. Genome medicine	F Wang, Y Li, H Shen, P Martinez-Feduchi, X Ji, P Teng, S Krishnakumar, J Hu, L Chen, Y Feng, B Yao	11/11/2024
Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2. Communications biology	F Zhao, Y Li, L Chen, B Yao	10/19/2024
New ZNHIT3 Variants Disrupting snoRNP Assembly Cause Prenatal PEHO Syndrome with Isolated Hydrops. medRxiv : the preprint server for health sciences	ML Rahman, AA Bonnard, F Wang, L Ruaud, F Guimiot, Y Li, I Defer, Y Wang, V Marchand, Y Motorin, B Yao, S Drunat, H Ghalei	08/26/2024
scaDA: A novel statistical method for differential analysis of single-cell chromatin accessibility sequencing data. PLoS computational biology	F Zhao, X Ma, B Yao, Q Lu, L Chen	08/01/2024
Isoform balance of the long noncoding RNA NEAT1 is regulated by the RNA-binding protein QKI, governs the glioma transcriptome, and impacts cell migration. The Journal of biological chemistry	PM Zakutansky, L Ku, G Zhang, L Shi, Y Li, B Yao, GJ Bassell, RD Read, Y Feng	08/01/2024
Bridging the gap: R-loop mediated genomic instability and its implications in neurological diseases. Epigenomics	KR Westover, P Jin, B Yao	03/26/2024
Deep5hmC: Predicting genome-wide 5-Hydroxymethylcytosine landscape via a multimodal deep learning model. bioRxiv : the preprint server for biology	X Ma, SR Thela, F Zhao, B Yao, Z Wen, P Jin, J Zhao, L Chen	03/06/2024
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops). The Journal of biological chemistry	JL de Amorim, SW Leung, R Haji-Seyed-Javadi, Y Hou, DS Yu, H Ghalei, S Khoshnevis, B Yao, AH Corbett	02/01/2024
scaDA: A Novel Statistical Method for Differential Analysis of Single-Cell Chromatin Accessibility Sequencing Data. bioRxiv : the preprint server for biology	F Zhao, X Ma, B Yao, L Chen	01/24/2024
TDP-43 chronic deficiency leads to dysregulation of transposable elements and gene expression by affecting R-loop and 5hmC crosstalk. Cell reports	Y Hou, Y Li, JF Xiang, K Tilahun, J Jiang, VG Corces, B Yao	01/23/2024
Epigenetic modifications of DNA and RNA in Alzheimer's disease. Frontiers in molecular neuroscience	P Martinez-Feduchi, P Jin, B Yao	01/01/2024
Brain methylome remodeling selectively regulates neuronal activity genes linking to emotional behaviors in mice exposed to maternal immune activation. Nature communications	L Ma, F Wang, Y Li, J Wang, Q Chang, Y Du, J Sadan, Z Zhao, G Fan, B Yao, JF Chen	11/29/2023
Social defeat stress induces genome-wide 5mC and 5hmC alterations in the mouse brain. G3 (Bethesda, Md.)	JN Kuehner, NR Walia, R Seong, Y Li, P Martinez-Feduchi, B Yao	08/09/2023
The human lncRNA GOMAFU suppresses neuronal interferon response pathways affected in neuropsychiatric diseases. Brain, behavior, and immunity	P Teng, Y Li, L Ku, F Wang, DR Goldsmith, Z Wen, B Yao, Y Feng	08/01/2023
The RNA helicase DDX1 associates with the nuclear RNA exosome and modulates R-loops. bioRxiv : the preprint server for biology	JL de Amorim, SW Leung, R Haji-Seyed-Javadi, Y Hou, DS Yu, H Ghalei, S Khoshnevis, B Yao, AH Corbett	04/17/2023
Expression of expanded GGC repeats within NOTCH2NLC causes behavioral deficits and neurodegeneration in a mouse model of neuronal intranuclear inclusion disease. Science advances	Q Liu, K Zhang, Y Kang, Y Li, P Deng, Y Li, Y Tian, Q Sun, Y Tang, K Xu, Y Zhou, JL Wang, J Guo, JD Li, K Xia, Q Meng, EG Allen, Z Wen, Z Li, H Jiang, L Shen, R Duan, B Yao, B Tang, P Jin, Y Pan	11/25/2022
Accurate identification of circRNA landscape and complexity reveals their pivotal roles in human oligodendroglia differentiation. Genome biology	Y Li, F Wang, P Teng, L Ku, L Chen, Y Feng, B Yao	02/07/2022
Multi-task deep autoencoder to predict Alzheimer's disease progression using temporal DNA methylation data in peripheral blood. Computational and structural biotechnology journal	L Chen, AJ Saykin, B Yao, F Zhao	01/01/2022
Reversing neural circuit and behavior deficit in mice exposed to maternal inflammation by Zika virus. EMBO reports	L Ma, J Wang, J Ge, Y Wang, W Zhang, Y Du, J Luo, Y Li, F Wang, G Fan, R Chen, B Yao, Z Zhao, ML Guo, WK Kim, Y Chai, JF Chen	08/04/2021
5-hydroxymethylcytosine is dynamically regulated during forebrain organoid development and aberrantly altered in Alzheimer's disease. Cell reports	JN Kuehner, J Chen, EC Bruggeman, F Wang, Y Li, C Xu, ZT McEachin, Z Li, L Chen, CM Hales, Z Wen, J Yang, B Yao	04/27/2021
N6-methyladenosine dynamics in neurodevelopment and aging, and its potential role in Alzheimer's disease. Genome biology	AM Shafik, F Zhang, Z Guo, Q Dai, K Pajdzik, Y Li, Y Kang, B Yao, H Wu, C He, EG Allen, R Duan, P Jin	01/05/2021
circMeta: a unified computational framework for genomic feature annotation and differential expression analysis of circular RNAs. Bioinformatics (Oxford, England)	L Chen, F Wang, EC Bruggeman, C Li, B Yao	01/15/2020
Developmental changes and sex differences in DNA methylation and demethylation in hypothalamic regions of the mouse brain. Epigenetics	CD Cisternas, LR Cortes, EC Bruggeman, B Yao, NG Forger	01/01/2020
Brain microRNAs associated with late-life depressive symptoms are also associated with cognitive trajectory and dementia. NPJ genomic medicine	TS Wingo, J Yang, W Fan, S Min Canon, ES Gerasimov, A Lori, B Logsdon, B Yao, NT Seyfried, JJ Lah, AI Levey, PA Boyle, JA Schneider, PL De Jager, DA Bennett, AP Wingo	01/01/2020
The Taiman Transcriptional Coactivator Engages Toll Signals to Promote Apoptosis and Intertissue Invasion in Drosophila. Current biology : CB	PK Byun, C Zhang, B Yao, J Wardwell-Ozgo, D Terry, P Jin, K Moberg	09/09/2019
TIVAN: tissue-specific cis-eQTL single nucleotide variant annotation and prediction. Bioinformatics (Oxford, England)	L Chen, Y Wang, B Yao, A Mitra, X Wang, X Qin	05/01/2019
Reversing Behavioral, Neuroanatomical, and Germline Influences of Intergenerational Stress. Biological psychiatry	HS Aoued, S Sannigrahi, N Doshi, FG Morrison, H Linsenbaum, SC Hunter, H Walum, J Baman, B Yao, P Jin, KJ Ressler, BG Dias	02/01/2019
The Dynamic Partnership of Polycomb and Trithorax in Brain Development and Diseases. Epigenomes	JN Kuehner, B Yao	01/01/2019
Epigenetic Regulations in Neuropsychiatric Disorders. Frontiers in genetics	JN Kuehner, EC Bruggeman, Z Wen, B Yao	01/01/2019
Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice. Cell reports	Y Cheng, M Sun, L Chen, Y Li, L Lin, B Yao, Z Li, Z Wang, J Chen, Z Miao, N Xin, L Huang, EG Allen, H Wu, X Xu, P Jin	12/11/2018
Active N⁶-Methyladenine Demethylation by DMAD Regulates Gene Expression by Coordinating with Polycomb Protein in Neurons. Molecular cell	B Yao, Y Li, Z Wang, L Chen, M Poidevin, C Zhang, L Lin, F Wang, H Bao, B Jiao, J Lim, Y Cheng, L Huang, BL Phillips, T Xu, R Duan, KH Moberg, H Wu, P Jin	09/06/2018
A unique epigenomic landscape defines the characteristics and differentiation potentials of glioma stem cells. Genome biology	B Yao, P Jin	04/10/2018