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Emory Cellular and Immunotherapy Core

The Emory Cellular and Immunotherapy Core is a clinical cell manufacturing facility that prepares cell and immunotherapy products for the development of investigational new drugs and diagnostic methods.

Overview

The Emory Cellular and Immunotherapy Core (ExCITE) provides cell manufacturing compliant with Good Manufacturing Practices and consultation for translating Emory-based or external research collaborations into early-phase clinical trials.

Our dedicated office (T4L64) and laboratory space are located on the fourth floor of the Emory University Hospital tower. This space includes computational services and areas for meeting customers and holding team meetings. Additionally, we have meeting rooms available in Winship's Shared Resource Hub on the third floor of The Emory Clinic, Building B.

Standard processes performed include the isolation, expansion, and cryopreservation of mesenchymal stem/stromal cells and dendritic cells, as well as the transduction and/or transfection of lymphocytes and other cellular products for investigational new FDA-sanctioned studies.

Services and Equipment

The types of products routinely handled include:

  • Autologous and allogeneic mesenchymal cells
  • Apheresis cell products for chimeric antigen receptor (CAR) transduction
  • Allogenic red blood cells for labelling
  • Autologous dendritic cell fusions
  • Cardiomyocyte manipulation for pediatric use
  • Cellular products from external companies

Equipment located within our space includes:

  • Seven laminar flow hoods
  • Sixteen CO2 incubators
  • Four swinging bucket temperature-controlled centrifuges
  • A suite of Miltenyi CAR (chimeric antigen receptor) production equipment including MACSQuant and Prodigy
  • Endosafe Nexgen PTS instruments for endotoxin detection
  • Lonza mycoplasma detection instruments
  • QuantStudio S5 Real-Time PCR System
  • An ISBT label printer and computer equipment as needed

Publication Acknowledgement Policy

The National Cancer Institute requires that publications acknowledge the Winship Cancer Institute Cancer Center Support Grant (CCSG), and it is tracking compliance. If a Winship Cancer Institute CCSG-supported Shared Resource provided data, designed the study, performed analyses, provided results used in your publication, and/or provided any systems or services that were used for the work that resulted in your publication, please include the following statement in the acknowledgment section of your publication(s):

Research reported in this publication was supported in part by the Emory Cellular and Immunotherapy Core of Winship Cancer Institute of Emory University and NIH/NCI under award number P30CA138292. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.